Salles-Dias Lucas P, Brandao-Rangel Maysa A R, Cristina-Rosa Amanda, Morais-Felix Rayssa T, Oliveira-Freitas Simone, Oliveira Luis V F, Moraes-Ferreira Renilson, Bachi Andre L L, Coutinho Elisa T, Frison Claudio R, Abbasi Asghar, Melamed Dobroslav, Vieira Rodolfo P
Post-graduate Program in Bioengineering, Universidade Brasil, São Paulo, SP, Brazil.
Post-graduate Program in Sciences of Human Movement and Rehabilitation, Federal University of São Paulo (UNIFESP), Santos, SP, Brazil.
J Asthma. 2024 Oct;61(10):1284-1293. doi: 10.1080/02770903.2024.2338862. Epub 2024 Apr 19.
Asthmatic children present variable degrees of airway inflammation, remodeling, and resistance, which correlate with disease control and severity. The chronic inflammatory process of the airway triggers airway remodeling, which reflects the degree of airway resistance. Pro-inflammatory and pro-fibrotic mediators are centrally involved in this process.
To investigate whether the levels of pulmonary and systemic pro-inflammatory and pro-fibrotic mediators present a correlation with the resistance of the respiratory system and of the proximal and distal airways.
39 Asthmatic children (persistent mild and moderate) and 39 non-asthmatic children (both between 6 and 13 years old) were evaluated for anthropometric characteristics, lung function and mechanics, and pulmonary and systemic immune responses.
Asthmatic children showed an increased number of blood eosinophils ( < 0.04), basophils ( < 0.04), monocytes ( < 0.002) and lymphocytes ( < 0.03). In addition, asthmatic children showed impaired lung function, as demonstrated by FEV1 ( < 0.0005) and FEV1/FVC ( < 0.004), decreased total resistance of the respiratory system (R5Hz; < 0.009), increased resistance of the proximal airways (R20Hz; < 0.02), increased elastance (Z5Hz; < 0.02) and increased reactance (X5Hz; < 0.002) compared to non-asthmatic children. Moreover, the following inflammatory factors were significantly higher in asthmatic than non-asthmatic children: GM-CSF in the breath condensate (BC) ( < 0.0001) and in the serum ( < 0.0001); TGF-beta in the BC ( < 0.0001) and in the serum ( < 0.004); IL-5 in the BC ( < 0.02) and in the serum ( < 0.01); IL-4 in the serum ( < 0.0002).
Impulse oscillometry is a sensitive method to detect airway resistance in persistent mild and moderate asthmatic children, an event followed by increased levels of pro-inflammatory and pro-fibrotic mediators.
哮喘儿童存在不同程度的气道炎症、重塑和阻力，这些与疾病控制和严重程度相关。气道的慢性炎症过程引发气道重塑，而气道重塑反映气道阻力程度。促炎和促纤维化介质在这一过程中起核心作用。
研究肺和全身促炎及促纤维化介质水平是否与呼吸系统以及近端和远端气道的阻力相关。
对39名哮喘儿童（持续性轻度和中度）和39名非哮喘儿童（年龄均在6至13岁之间）进行人体测量学特征、肺功能和力学以及肺和全身免疫反应评估。
哮喘儿童血液中的嗜酸性粒细胞（<0.04）、嗜碱性粒细胞（<0.04）、单核细胞（<0.002）和淋巴细胞（<0.
