Clinic of Respiratory Failure, General Hospital of Thessaloniki 'Georgios Papanikolaou', Aristotle University of Thessaloniki, Thessaloniki, Greece.
Department of Pulmonary Medicine, General Hospital of Thessaloniki 'Georgios Papanikolaou', Aristotle University of Thessaloniki, Thessaloniki, Greece.
Respirology. 2020 Oct;25(10):1037-1045. doi: 10.1111/resp.13806. Epub 2020 Apr 2.
The acute effects of e-cigarettes have not been scientifically demonstrated yet. The aim of this study was to assess the acute changes in pulmonary function and airway inflammation in patients with asthma after vaping one e-cigarette.
Twenty-five smokers suffering from stable moderate asthma according to GINA guidelines with no other comorbidities and 25 healthy smokers matched with the baseline characteristics of the asthmatic patients were recruited. PFT, IOS, FeNO and EBC were performed before and after vaping one e-cigarette with nicotine. pH and concentrations of IL-1β, IL-4, IL-5, IL-6, IL-8, IL-10, IL-13, IL-17A, TNF-α, ISO8 and LTB4 were measured in EBC.
FFEV1/FVC ratio and PEF were reduced in asthmatic patients after e-cigarette. Z5Hz and R5Hz, R10Hz and R20Hz increased in both groups. FeNO and EBC pH increased by 3.60 ppb (P = 0.001) and 0.15 (P = 0.014) in asthmatic patients after e-cigarette, whereas they decreased in control group by 3.28 ppb (P < 0.001) and 0.12 (P = 0.064), respectively. The concentrations of IL-10, TNF-α and ISO8 in EBC increased in asthmatic patients after e-cigarette and the changes in concentrations of IL-1β and IL-4 differed significantly between the two groups.
E-cigarette vaping resulted in acute alteration of both pulmonary function and airway inflammation in stable moderate asthmatic patients.
电子烟的急性效应尚未得到科学证明。本研究旨在评估电子烟吸食后哮喘患者的肺功能和气道炎症的急性变化。
根据 GINA 指南，我们招募了 25 名患有稳定中度哮喘且无其他合并症的吸烟者和 25 名与哮喘患者基线特征匹配的健康吸烟者。在吸完一支含尼古丁的电子烟前后，我们进行了 PFT、IOS、FeNO 和 EBC 检查。在 EBC 中测量了 pH 值以及 IL-1β、IL-4、IL-5、IL-6、IL-8、IL-10、IL-13、IL-17A、TNF-α、ISO8 和 LTB4 的浓度。
电子烟吸食后哮喘患者的 FEV1/FVC 比值和 PEF 降低。两组的 Z5Hz 和 R5Hz、R10Hz 和 R20Hz 均增加。电子烟吸食后哮喘患者的 FeNO 和 EBC pH 值分别增加了 3.60 ppb（P = 0.001）和 0.15（P = 0.014），而对照组分别降低了 3.28 ppb（P < 0.001）和 0.12（P = 0.064）。EBC 中 IL-10、TNF-α 和 ISO8 的浓度在哮喘患者吸电子烟后增加，而两组之间 IL-1β 和 IL-4 浓度的变化差异显著。
电子烟吸食会导致稳定中度哮喘患者的肺功能和气道炎症急性改变。
