Department of Medical Laboratory Science, Kampala International University, Kampala, Uganda.
School of Nursing Science, Kampala International University, Kampala, Uganda.
Medicine (Baltimore). 2024 Apr 5;103(14):e37649. doi: 10.1097/MD.0000000000037649.
The co-occurrence of human immunodeficiency virus and malaria presents a complex medical scenario, significantly impacting the quality of life for affected individuals. This comprehensive review synthesizes current knowledge, challenges, and strategies concerning the concurrent management of these infections to improve overall well-being. Epidemiological insights reveal the prevalence and demographic trends, highlighting geographical areas of concern and socioeconomic factors contributing to the burden of co-infection. Pathophysiological interactions elucidate the compounding effects, altering disease progression and treatment outcomes. Healthcare challenges underscore the necessity for integrated care models, evaluating existing healthcare frameworks and their efficacy in addressing dual infections. In-depth analysis of interventions explores pharmacological, behavioral, and preventive measures, evaluating their efficacy and safety in co-infected individuals. Additionally, the review assesses psychosocial support mechanisms, emphasizing community-based interventions and peer networks in enhancing holistic care. Consideration is given to the role of antiretroviral therapy, malaria prevention strategies, and the evolving landscape of healthcare delivery in optimizing outcomes for this vulnerable population. The paper concludes by emphasizing the significance of multidisciplinary approaches and integrated care models, stressing the need for continued research and collaborative efforts to advance interventions and improve the quality of life for those navigating the complexities of human immunodeficiency virus and malaria co-infection.
人类免疫缺陷病毒(HIV)与疟疾的共同发生呈现出复杂的医学状况,极大地影响了受影响个体的生活质量。本综述综合了当前关于这两种感染同时管理的知识、挑战和策略,以改善整体健康状况。流行病学观点揭示了流行情况和人口统计学趋势,重点关注令人关注的地理区域以及导致合并感染负担的社会经济因素。病理生理学相互作用阐明了复合效应,改变了疾病进展和治疗结果。医疗保健挑战强调了整合护理模式的必要性,评估了现有医疗保健框架及其在解决双重感染方面的效果。对干预措施的深入分析探讨了药理学、行为学和预防措施,评估了它们在合并感染个体中的疗效和安全性。此外,该综述还评估了心理社会支持机制,强调了以社区为基础的干预措施和同伴网络在增强整体护理方面的作用。文中还考虑了抗逆转录病毒疗法、疟疾预防策略以及医疗保健提供方式的发展动态,以优化这一脆弱人群的治疗效果。本文最后强调了多学科方法和综合护理模式的重要性,强调需要继续进行研究和协作努力,以推进干预措施并改善那些应对人类免疫缺陷病毒与疟疾合并感染复杂性的个体的生活质量。