School of Nutrition Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.
Department of Chemistry and Biomolecular Sciences, Faculty of Science, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada.
J Agric Food Chem. 2024 Apr 17;72(15):8372-8379. doi: 10.1021/acs.jafc.4c01385. Epub 2024 Apr 5.
Self-assembling peptides are rapidly gaining attention as novel biomaterials for food and biomedical applications. Peptides self-assemble when triggered by physical or chemical factors due to their versatile physicochemical characteristics. Peptide self-assembly, when combined with the health-promoting bioactivity of peptides, can also result in a plethora of biofunctionalities of the biomaterials. This perspective highlights current developments in the use of food-derived self-assembling peptides as biomaterials, bioactive nutraceuticals, and potential dual functioning bioactive biomaterials. Also discussed are the challenges and opportunities in the use of self-assembling bioactive peptides in designing biocompatible, biostable, and bioavailable multipurpose biomaterials.
自组装肽作为新型的食品和生物医学应用的生物材料,正受到越来越多的关注。由于其多样的物理化学特性,肽在受到物理或化学因素的触发时会自行组装。当肽的自组装与肽的促进健康的生物活性相结合时,也会导致生物材料具有多种生物功能。本观点重点介绍了目前在将源自食品的自组装肽用作生物材料、生物活性营养保健品和潜在的双重功能生物活性生物材料方面的最新进展。还讨论了在设计具有生物相容性、生物稳定性和生物可利用性的多用途生物材料时,使用自组装生物活性肽所面临的挑战和机遇。