Kamineni Academy of Medical Sciences and Research Center, Hyderabad, India; PearResearch, Dehradun, India.
PearResearch, Dehradun, India; Shri Bhausaheb Hire Govt. Medical College, Dhule, Maharashtra, India.
Diabetes Metab Syndr. 2024 Mar;18(3):102994. doi: 10.1016/j.dsx.2024.102994. Epub 2024 Mar 29.
Diabetic gastroparesis (DGp) is a common and preventable complication of uncontrolled diabetes mellitus (D.M.) and significantly affects the Quality of Life of patients. Diagnosis and management present as a clinical challenge due to the disease's complexity and limited effective therapeutic options. This review aims to comprehensively outline the pathogenesis, diagnosis, and management of diabetic gastroparesis, evaluating evolving approaches to guide clinicians and provide future recommendations.
A literature review was conducted on scholarly databases of PubMed, Google Scholar, Scopus and Web of Science encompassing published articles, gray literature and relevant clinical guidelines. Data were synthesized and analyzed to provide a comprehensive overview of diabetic gastroparesis, focusing on pathogenesis, diagnosis, and management.
The review intricately explores the pathogenesis contributing to diabetic gastroparesis, emphasizing autonomic neuropathy, oxidative stress, inflammation, hormonal dysregulation, microbiota alterations, and gastrointestinal neuropathy. Primary management strategies are underscored, including lifestyle modifications, symptom relief, and glycemic control. The discussion encompasses pharmacological and surgical options, highlighting the importance of a multidisciplinary approach involving various healthcare professionals for comprehensive patient care.
This review offers a thorough understanding of pathogenesis, diagnosis, and management of diabetic gastroparesis, underlining evolving approaches for clinicians. A multidisciplinary approach is crucial to address both the physical and mental health aspects of diabetes and its complications.
糖尿病性胃轻瘫（DGp）是一种常见且可预防的糖尿病控制不良的并发症，严重影响患者的生活质量。由于疾病的复杂性和有限的有效治疗选择，诊断和治疗具有临床挑战性。本综述旨在全面概述糖尿病性胃轻瘫的发病机制、诊断和治疗，评估不断发展的方法以指导临床医生并提供未来建议。
对 PubMed、Google Scholar、Scopus 和 Web of Science 等学术数据库进行文献回顾，涵盖已发表的文章、灰色文献和相关临床指南。对数据进行综合和分析，提供糖尿病性胃轻瘫的全面概述，重点关注发病机制、诊断和治疗。
本综述深入探讨了导致糖尿病性胃轻瘫的发病机制，强调自主神经病变、氧化应激、炎症、激素失调、微生物群改变和胃肠神经病变。强调了主要的管理策略，包括生活方式改变、症状缓解和血糖控制。讨论涵盖了药物和手术选择，强调了多学科方法的重要性，涉及各种医疗保健专业人员，以提供全面的患者护理。
本综述提供了对糖尿病性胃轻瘫发病机制、诊断和治疗的全面理解，强调了临床医生不断发展的方法。多学科方法对于解决糖尿病及其并发症的身体和心理健康方面至关重要。
