Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China.
Department of Maternal, Child and Adolescent Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China.
J Trace Elem Med Biol. 2024 Jul;84:127426. doi: 10.1016/j.jtemb.2024.127426. Epub 2024 Mar 9.
Animal studies have shown that exposure to REEs can cause severe liver damage, but evidence from population studies is still lacking. Therefore, we investigated the relationship between REEs concentrations in urine and liver function in the population.
We conducted a cross-sectional study on 1024 participants in Nanning, China. An inductively coupled plasma mass spectrometer (ICP-MS) was used to detect the concentrations of 12 REEs in urine. The relationship between individual exposure to individual REE and liver function was analyzed by multiple linear regression. Finally, the effects of co-exposure to 5 REEs on liver function were assessed by a weighted sum of quartiles (WQS) regression model and a Bayesian kernel machine regression (BKMR) model.
The detection rate of 5 REEs, lanthanum (La), cerium (Ce), praseodymium (Pr), neodymium (Nd), and dysprosium (Dy), is greater than 60%. After multiple factor correction, La, Ce, Pr, Nd, and Dy were positively correlated with serum ALP, Ce, Pr, and Nd were positively correlated with serum AST, while Ce was negatively correlated with serum TBIL and DBIL. Both WQS and BKMR results indicate that the co-exposure of the 5 REEs is positively correlated with serum ALP and AST, while negatively correlated with serum DBIL. There were potential interactions between La and Ce, La and Dy in the association of co-exposure of the 5 REEs with serum ALP.
The co-exposure of the 5 REEs was positively correlated with serum ALP and AST, and negatively correlated with serum DBIL.
动物研究表明，接触稀土元素会导致严重的肝损伤，但人群研究的证据仍然缺乏。因此，我们调查了人群尿液中稀土元素浓度与肝功能之间的关系。
我们在中国南宁进行了一项横断面研究，共纳入 1024 名参与者。采用电感耦合等离子体质谱仪（ICP-MS）检测尿液中 12 种稀土元素的浓度。采用多元线性回归分析个体暴露于个体稀土元素与肝功能之间的关系。最后，采用加权和四分位数（WQS）回归模型和贝叶斯核机器回归（BKMR）模型评估 5 种稀土元素共暴露对肝功能的影响。
5 种稀土元素镧（La）、铈（Ce）、镨（Pr）、钕（Nd）和镝（Dy）的检出率均大于 60%。经多因素校正后，La、Ce、Pr、Nd 和 Dy 与血清碱性磷酸酶（ALP）呈正相关，Ce、Pr 和 Nd 与血清天冬氨酸转氨酶（AST）呈正相关，而 Ce 与血清总胆红素（TBIL）和直接胆红素（DBIL）呈负相关。WQS 和 BKMR 结果均表明，5 种稀土元素共暴露与血清 ALP 和 AST 呈正相关，与血清 DBIL 呈负相关。La 和 Ce、La 和 Dy 之间存在潜在的交互作用，与 5 种稀土元素共暴露与血清 ALP 的相关性有关。
5 种稀土元素共暴露与血清 ALP 和 AST 呈正相关，与血清 DBIL 呈负相关。
