School of Psychology and Key Laboratory of Cognition and Personality (Ministry of Education); National Demonstration Center for Experimental Psychology Education, Southwest University, Chongqing 400715, China.
Medical and Health Analysis Center, Peking University, Beijing 100191, China.
Int J Environ Res Public Health. 2020 Feb 21;17(4):1399. doi: 10.3390/ijerph17041399.
The current study aims to investigate the influence of five rare earth elements (REEs) (i.e., lanthanum (La), cerium (Ce), praseodymium (Pr), neodymium (Nd), and gadolinium (Gd)) on the growth of Sprague-Dawley (SD) rats, and to explore the accumulation characteristics of REEs in tissues and organs with different doses as well as the detoxification and elimination of high-dose REEs. Fifty healthy male SD rats (140~160 g) were randomly divided into five groups and four of them were given gavage of sodium citrate solution with REEs in different doses, one of which was the control group. Hair, blood, and bone samples along with specific viscera tissue samples from the spleen and the liver were collected for detection of REEs by Inductively Coupled Plasma-Mass Spectrometry (ICP-MS). Treated rats expressed higher concentrations of REEs in the bones, the liver, and spleen samples than the control group ( < 0.05). Few differences were found in relative abundance of La, Ce, Pr, Nd, and Gd in the hair and the liver samples, although different administration doses were given. The relative abundance of Ce in bone samples was significantly lower in the low-dose group and control group, whereas the relative abundance of La and Pr in the bone samples were highest among all groups. Although in the REEs solution, which was given to rats in high-dose group, the La element had a higher relative abundance than Ce element, it ended up with higher Ce element relative abundance than La element in the spleen samples. REEs had a hormetic effect on body weight gain of SD rats. The accumulation of the measured REEs were reversible to low concentrations in the blood and hair, but non-reversible in the bones, the spleen, and the liver. Different tissues and organs can selectively absorb and accumulate REEs. Further inter-disciplinary studies about REEs are urgently needed to identify their toxic effects on both ecosystems and organisms.
本研究旨在探讨五种稀土元素（REES）（即镧（La）、铈（Ce）、镨（Pr）、钕（Nd）和钆（Gd））对 Sprague-Dawley（SD）大鼠生长的影响，并探索不同剂量下 REEs 在组织和器官中的积累特征以及高剂量 REEs 的解毒和消除。将 50 只健康雄性 SD 大鼠（140-160g）随机分为五组，其中四组给予不同剂量的柠檬酸钠溶液灌胃，一组为对照组。采集毛发、血液和骨骼样本以及脾和肝的特定组织样本，通过电感耦合等离子体质谱法（ICP-MS）检测 REEs。与对照组相比，处理组大鼠的骨骼、肝脏和脾脏样本中的 REEs 浓度更高（<0.05）。虽然给予了不同的给药剂量，但在毛发和肝脏样本中，La、Ce、Pr、Nd 和 Gd 的相对丰度差异不大。低剂量组和对照组骨样本中 Ce 的相对丰度明显较低，而所有组中骨样本中 La 和 Pr 的相对丰度最高。虽然在高剂量组大鼠给予的 REEs 溶液中，La 元素的相对丰度高于 Ce 元素，但脾样本中 Ce 元素的相对丰度却高于 La 元素。REEs 对 SD 大鼠体重增长具有兴奋作用。在血液和毛发中，低浓度的 REEs 可以被可逆地积累，但在骨骼、脾脏和肝脏中则不可逆转。不同的组织和器官可以选择性地吸收和积累 REEs。需要进一步开展跨学科研究，以确定 REEs 对生态系统和生物体的毒性影响。
