Tao Wei, Zhang Yanren, Wang Bingbin, Nie Saiqun, Fang Li, Xiao Jian, Wu Yanqing
The Institute of Life Sciences, Wenzhou University, Wenzhou 325035, China.
School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
J Adv Res. 2025 Mar;69:261-278. doi: 10.1016/j.jare.2024.03.023. Epub 2024 Apr 3.
Central nervous system (CNS) diseases pose a serious threat to human health, but the regulatory mechanisms and therapeutic strategies of CNS diseases need to be further explored. It has been demonstrated that the gut microbiota (GM) is closely related to CNS disease. GM structure disorders, abnormal microbial metabolites, intestinal barrier destruction and elevated inflammation exist in patients with CNS diseases and promote the development of CNS diseases. More importantly, GM remodeling alleviates CNS pathology to some extent.
Here, we have summarized the regulatory mechanism of the GM in CNS diseases and the potential treatment strategies for CNS repair based on GM regulation, aiming to provide safer and more effective strategies for CNS repair from the perspective of GM regulation.
The abundance and composition of GM is closely associated with the CNS diseases. On the basis of in-depth analysis of GM changes in mice with CNS disease, as well as the changes in its metabolites, therapeutic strategies, such as probiotics, prebiotics, and FMT, may be used to regulate GM balance and affect its microbial metabolites, thereby promoting the recovery of CNS diseases.
中枢神经系统（CNS）疾病对人类健康构成严重威胁，但中枢神经系统疾病的调控机制和治疗策略仍需进一步探索。已有研究表明，肠道微生物群（GM）与中枢神经系统疾病密切相关。中枢神经系统疾病患者存在肠道微生物群结构紊乱、微生物代谢产物异常、肠道屏障破坏及炎症反应增强等情况，这些因素促进了中枢神经系统疾病的发展。更重要的是，肠道微生物群重塑在一定程度上可减轻中枢神经系统病理改变。
在此，我们总结了肠道微生物群在中枢神经系统疾病中的调控机制以及基于肠道微生物群调控的中枢神经系统修复潜在治疗策略，旨在从肠道微生物群调控角度为中枢神经系统修复提供更安全、有效的策略。
肠道微生物群的丰度和组成与中枢神经系统疾病密切相关。在深入分析中枢神经系统疾病小鼠肠道微生物群变化及其代谢产物变化的基础上，益生菌、益生元及粪菌移植等治疗策略可用于调节肠道微生物群平衡并影响其微生物代谢产物，从而促进中枢神经系统疾病的恢复。
