Bullerdiek J, Bartnitzke S, Kahrs E, Schloot W
Cytobios. 1985;42(165):15-24.
A high number of structurally altered marker chromosomes was found in two cases of ovarian carcinoma. Even by the application of different staining methods it was not possible to identify all the chromosomes. No evidence for the existence of a translocation between chromosomes 6 and 14 was found, which seems to be a specific abnormality characteristic of papillary serous cystadenocarcinomas of the ovary. It is of interest that double minutes were present in both cases. This offers further evidence for the assumption that double minutes are not infrequent in carcinomas. Their orthodox mitotic behaviour leads to high karyotype variability (number of double minutes/cell), and may be of particular importance for tumour biology. The methodological and cytogenetic implications of the results are discussed.
在两例卵巢癌病例中发现了大量结构改变的标记染色体。即使应用不同的染色方法，也无法识别所有染色体。未发现6号和14号染色体之间存在易位的证据，而这似乎是卵巢乳头状浆液性囊腺癌的一种特异性异常特征。有趣的是，两例病例中均存在双微体。这为双微体在癌中并不罕见的假设提供了进一步证据。它们正常的有丝分裂行为导致了高核型变异性（双微体/细胞数量），并且可能对肿瘤生物学具有特别重要的意义。讨论了这些结果的方法学和细胞遗传学意义。
