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An unclear role for the GLP-1 metabolite GLP-1(9-36) in human islet physiology.

作者信息

Matveyenko Aleksey, Vella Adrian

机构信息

Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN, USA.

Division of Endocrinology, Diabetes & Metabolism, Mayo Clinic College of Medicine, Rochester, MN, USA.

出版信息

Diabetologia. 2024 Jul;67(7):1444-1445. doi: 10.1007/s00125-024-06141-4. Epub 2024 Apr 6.

DOI:10.1007/s00125-024-06141-4
PMID:38580845
Abstract
摘要

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An unclear role for the GLP-1 metabolite GLP-1(9-36) in human islet physiology.胰高血糖素样肽-1代谢产物GLP-1(9-36)在人类胰岛生理学中的作用尚不明确。
Diabetologia. 2024 Jul;67(7):1444-1445. doi: 10.1007/s00125-024-06141-4. Epub 2024 Apr 6.
2
An unclear role for the GLP-1 metabolite GLP-1(9-36) in human islet physiology. Reply to Matveyenko A, Vella A [letter].胰高血糖素样肽-1代谢产物GLP-1(9-36)在人类胰岛生理学中的作用尚不明确。对马特韦延科A、韦拉A[信件]的回复。
Diabetologia. 2024 Jul;67(7):1446-1447. doi: 10.1007/s00125-024-06140-5. Epub 2024 Apr 5.
3
Glucagon-like peptide-1 and islet lipolysis.胰高血糖素样肽-1与胰岛脂肪分解
Horm Metab Res. 2004 Nov-Dec;36(11-12):795-803. doi: 10.1055/s-2004-826166.
4
Intra-islet regulation of hormone secretion by glucagon-like peptide-1-(7--36) amide.胰高血糖素样肽-1（7-36）酰胺对胰岛内激素分泌的调节
Am J Physiol. 1995 Dec;269(6 Pt 1):G852-60. doi: 10.1152/ajpgi.1995.269.6.G852.
5
Human islets contain a subpopulation of glucagon-like peptide-1 secreting α cells that is increased in type 2 diabetes.人类胰岛中存在一群胰高血糖素样肽-1 分泌的α细胞，在 2 型糖尿病中这群细胞的数量会增加。
Mol Metab. 2020 Sep;39:101014. doi: 10.1016/j.molmet.2020.101014. Epub 2020 May 12.
6
Engineered beta-cells secreting dipeptidyl peptidase IV-resistant glucagon-like peptide-1 show enhanced glucose-responsiveness.分泌二肽基肽酶IV抗性胰高血糖素样肽-1的工程化β细胞表现出增强的葡萄糖反应性。
Life Sci. 2005 Jan 28;76(11):1239-48. doi: 10.1016/j.lfs.2004.08.021. Epub 2004 Dec 8.
7
GLP-1 metabolite GLP-1(9-36) is a systemic inhibitor of mouse and human pancreatic islet glucagon secretion.胰高血糖素样肽-1代谢产物胰高血糖素样肽-1(9-36)是小鼠和人胰岛胰高血糖素分泌的全身性抑制剂。
Diabetologia. 2024 Mar;67(3):528-546. doi: 10.1007/s00125-023-06060-w. Epub 2023 Dec 21.
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Elimination of glucagon-like peptide 1R signaling does not modify weight gain and islet adaptation in mice with combined disruption of leptin and GLP-1 action.在瘦素和胰高血糖素样肽-1（GLP-1）作用联合缺失的小鼠中，消除GLP-1受体信号不会改变体重增加和胰岛适应性。
Diabetes. 2000 Sep;49(9):1552-60. doi: 10.2337/diabetes.49.9.1552.
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Mouse pancreatic beta-cells exhibit preserved glucose competence after disruption of the glucagon-like peptide-1 receptor gene.在胰高血糖素样肽-1受体基因被破坏后，小鼠胰腺β细胞仍表现出保留的葡萄糖反应能力。
Diabetes. 1998 Apr;47(4):646-52. doi: 10.2337/diabetes.47.4.646.
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beta-Cell Pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective actions of glucagon-like peptide-1.β细胞中胰腺十二指肠同源盒因子1（Pdx1）的表达对于胰高血糖素样肽-1的血糖调节、增殖及细胞保护作用至关重要。
Diabetes. 2005 Feb;54(2):482-91. doi: 10.2337/diabetes.54.2.482.

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Molecular basis of enhanced GLP-1 signaling mediated by GLP-1(9-36) in conjunction with LSN3318839.GLP-1(9-36)与LSN3318839联合介导的GLP-1信号增强的分子基础
Acta Pharm Sin B. 2024 Nov;14(11):5069-5073. doi: 10.1016/j.apsb.2024.09.002. Epub 2024 Sep 6.

本文引用的文献

1
GLP-1 metabolite GLP-1(9-36) is a systemic inhibitor of mouse and human pancreatic islet glucagon secretion.胰高血糖素样肽-1代谢产物胰高血糖素样肽-1(9-36)是小鼠和人胰岛胰高血糖素分泌的全身性抑制剂。
Diabetologia. 2024 Mar;67(3):528-546. doi: 10.1007/s00125-023-06060-w. Epub 2023 Dec 21.
2
Glucagon-like peptide-1 receptor blockade impairs islet secretion and glucose metabolism in humans.胰高血糖素样肽-1受体阻断会损害人类胰岛分泌和葡萄糖代谢。
J Clin Invest. 2023 Nov 15;133(22):e173495. doi: 10.1172/JCI173495.
3
Human islets contain a subpopulation of glucagon-like peptide-1 secreting α cells that is increased in type 2 diabetes.
人类胰岛中存在一群胰高血糖素样肽-1 分泌的α细胞，在 2 型糖尿病中这群细胞的数量会增加。
Mol Metab. 2020 Sep;39:101014. doi: 10.1016/j.molmet.2020.101014. Epub 2020 May 12.
4
Inability of Some Commercial Assays to Measure Suppression of Glucagon Secretion.某些商业检测方法无法测量胰高血糖素分泌的抑制情况。
J Diabetes Res. 2016;2016:8352957. doi: 10.1155/2016/8352957. Epub 2015 Dec 29.
5
Direct effects of exendin-(9,39) and GLP-1-(9,36)amide on insulin action, β-cell function, and glucose metabolism in nondiabetic subjects.外泌素-(9,39)和 GLP-1-(9,36)酰胺对非糖尿病患者胰岛素作用、β细胞功能和葡萄糖代谢的直接影响。
Diabetes. 2013 Aug;62(8):2752-6. doi: 10.2337/db13-0140. Epub 2013 Apr 1.
6
Vildagliptin reduces glucagon during hyperglycemia and sustains glucagon counterregulation during hypoglycemia in type 1 diabetes.维格列汀可降低 1 型糖尿病患者高血糖时的胰高血糖素水平，并在低血糖时持续抑制胰高血糖素的代偿作用。
J Clin Endocrinol Metab. 2012 Oct;97(10):3799-806. doi: 10.1210/jc.2012-2332. Epub 2012 Aug 1.
7
GLP-1 (9-36) amide, cleavage product of GLP-1 (7-36) amide, is a glucoregulatory peptide.GLP-1（9-36）酰胺是GLP-1（7-36）酰胺的裂解产物，是一种调节血糖的肽。
Obesity (Silver Spring). 2008 Jul;16(7):1501-9. doi: 10.1038/oby.2008.229. Epub 2008 Apr 17.
8
Effects of GLP-1-(7-36)NH2, GLP-1-(7-37), and GLP-1- (9-36)NH2 on intravenous glucose tolerance and glucose-induced insulin secretion in healthy humans.GLP-1-(7-36)NH2、GLP-1-(7-37)和GLP-1-(9-36)NH2对健康人静脉葡萄糖耐量及葡萄糖诱导胰岛素分泌的影响。
J Clin Endocrinol Metab. 2003 Apr;88(4):1772-9. doi: 10.1210/jc.2002-021479.
9
Glucagon-like peptide-1-(7-36)amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine.胰高血糖素样肽-1-(7-36)酰胺在为猪肠道L细胞供血的毛细血管中被二肽基肽酶IV转化为胰高血糖素样肽-1-(9-36)酰胺。
Endocrinology. 1999 Nov;140(11):5356-63. doi: 10.1210/endo.140.11.7143.