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Molecular basis of enhanced GLP-1 signaling mediated by GLP-1(9-36) in conjunction with LSN3318839.

作者信息

Li Jie, Li Guanyi, Mai Yiting, Liu Xiao, Yang Dehua, Zhou Qingtong, Wang Ming-Wei

机构信息

Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.

School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai 200240, China.

出版信息

Acta Pharm Sin B. 2024 Nov;14(11):5069-5073. doi: 10.1016/j.apsb.2024.09.002. Epub 2024 Sep 6.

DOI:10.1016/j.apsb.2024.09.002
PMID:39664415
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11628842/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70a7/11628842/9dab8f70911b/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70a7/11628842/29498dd79c2c/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70a7/11628842/9dab8f70911b/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70a7/11628842/29498dd79c2c/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70a7/11628842/9dab8f70911b/gr2.jpg

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Molecular basis of enhanced GLP-1 signaling mediated by GLP-1(9-36) in conjunction with LSN3318839.GLP-1(9-36)与LSN3318839联合介导的GLP-1信号增强的分子基础
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本文引用的文献

1
An unclear role for the GLP-1 metabolite GLP-1(9-36) in human islet physiology.胰高血糖素样肽-1代谢产物GLP-1(9-36)在人类胰岛生理学中的作用尚不明确。
Diabetologia. 2024 Jul;67(7):1444-1445. doi: 10.1007/s00125-024-06141-4. Epub 2024 Apr 6.
2
GLP-1 metabolite GLP-1(9-36) is a systemic inhibitor of mouse and human pancreatic islet glucagon secretion.胰高血糖素样肽-1代谢产物胰高血糖素样肽-1(9-36)是小鼠和人胰岛胰高血糖素分泌的全身性抑制剂。
Diabetologia. 2024 Mar;67(3):528-546. doi: 10.1007/s00125-023-06060-w. Epub 2023 Dec 21.
3
GLP-1a: Going beyond Traditional Use.
GLP-1a:超越传统用途。
Int J Mol Sci. 2022 Jan 10;23(2):739. doi: 10.3390/ijms23020739.
4
The metabolite GLP-1 (9-36) is neuroprotective and anti-inflammatory in cellular models of neurodegeneration.GLP-1(9-36)代谢物在神经退行性变的细胞模型中具有神经保护和抗炎作用。
J Neurochem. 2021 Dec;159(5):867-886. doi: 10.1111/jnc.15521. Epub 2021 Oct 21.
5
Discovery of an Orally Efficacious Positive Allosteric Modulator of the Glucagon-like Peptide-1 Receptor.发现胰高血糖素样肽-1 受体的口服有效正变构调节剂。
J Med Chem. 2021 Mar 25;64(6):3439-3448. doi: 10.1021/acs.jmedchem.1c00029. Epub 2021 Mar 15.
6
Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists.肽类和非肽类激动剂对 GLP-1R 的差异化结合和激活。
Mol Cell. 2020 Nov 5;80(3):485-500.e7. doi: 10.1016/j.molcel.2020.09.020. Epub 2020 Oct 6.
7
Glucagon-like peptide-1 cleavage product GLP-1(9-36) reduces neuroinflammation from stroke via the activation of insulin-like growth factor 1 receptor in astrocytes.胰高血糖素样肽-1 裂解产物 GLP-1(9-36) 通过激活星形胶质细胞中的胰岛素样生长因子 1 受体来减轻中风引起的神经炎症。
Eur J Pharmacol. 2020 Nov 15;887:173581. doi: 10.1016/j.ejphar.2020.173581. Epub 2020 Sep 16.
8
Structural insights into probe-dependent positive allosterism of the GLP-1 receptor.GLP-1 受体探针依赖性正变构作用的结构见解。
Nat Chem Biol. 2020 Oct;16(10):1105-1110. doi: 10.1038/s41589-020-0589-7. Epub 2020 Jul 20.
9
Metabolically-inactive glucagon-like peptide-1(9-36)amide confers selective protective actions against post-myocardial infarction remodelling.代谢失活的胰高血糖素样肽-1(9-36)酰胺对心肌梗死后重塑具有选择性保护作用。
Cardiovasc Diabetol. 2016 Apr 14;15:65. doi: 10.1186/s12933-016-0386-5.
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Allosteric modulation of the activity of the glucagon-like peptide-1 (GLP-1) metabolite GLP-1 9-36 amide at the GLP-1 receptor.胰高血糖素样肽-1 (GLP-1) 代谢物 GLP-1 9-36 酰胺在 GLP-1 受体上对其活性的变构调节。
PLoS One. 2012;7(10):e47936. doi: 10.1371/journal.pone.0047936. Epub 2012 Oct 19.