Department of Toxicology, Faculty of Pharmacy, Wroclaw Medical University, Wroclaw, Poland.
Department of Minimally Invasive and Robotic Urology, University Center of Excellence in Urology, Wroclaw Medical University, Wroclaw, Poland.
J Physiol Pharmacol. 2024 Feb;75(1). doi: 10.26402/jpp.2024.1.08. Epub 2024 Apr 3.
Several cytokines have been indicated to be significantly involved in urological diseases. Interleukin 17A (IL-17A) and interleukin 23 (IL-23) have recently received attention for their involvement in inflammatory diseases and cancers. The aim of the study was to show changes in the level of pro-inflammatory interleukins IL-17A and IL-23 in patients with bladder cancer (BC) and selected urological diseases. An important cognitive aspect was to study the interdependencies between the studied interleukins and to assess their diagnostic value for such diseases. The material for the study was urine sample from patients with BC, urinary tract infection (UTI), urolithiasis, benign prostatic hyperplasia (BPH), US (urethral stricture), which was compared to the urine sample of healthy people without urological disorders. Interleukin concentrations were measured by the immunoenzymatic method. The levels of IL-17A and IL-23 in the urine of patients with BC, UTI, BPH and US were significantly higher compared to the control group. Statistically significant differences were found in the level of both interleukins compared to the control group in all diseases except urolithiasis. IL-17A and IL-23 correlated with each other in patients with all urological diseases except urolithiasis. The results of the conducted studies showed that selected urological diseases changed the levels of IL-17A and IL-23 in the urine of patients. The observations made confirmed the participation of these interleukins in the course of the urological diseases, especially in BC, and allowed to classify them as potentially useful parameters for diagnostic purposes.
几种细胞因子已被证明与泌尿系统疾病密切相关。白细胞介素 17A（IL-17A）和白细胞介素 23（IL-23）最近因其在炎症性疾病和癌症中的作用而受到关注。本研究旨在表明膀胱癌（BC）和某些泌尿外科疾病患者中促炎细胞因子 IL-17A 和 IL-23 的水平变化。一个重要的认知方面是研究研究中的细胞因子之间的相互关系，并评估它们对这些疾病的诊断价值。研究材料为 BC、尿路感染（UTI）、尿路结石、良性前列腺增生（BPH）、US（尿道狭窄）患者的尿液样本，与无泌尿外科疾病的健康人尿液样本进行比较。细胞因子浓度通过免疫酶法测量。与对照组相比，BC、UTI、BPH 和 US 患者尿液中的 IL-17A 和 IL-23 水平显著升高。除尿路结石外，与对照组相比，所有疾病中两种细胞因子的水平均存在统计学差异。除尿路结石外，所有泌尿外科疾病患者的 IL-17A 和 IL-23 相互关联。进行的研究结果表明，选定的泌尿外科疾病改变了患者尿液中 IL-17A 和 IL-23 的水平。这些观察结果证实了这些细胞因子参与了泌尿外科疾病的发生，尤其是在 BC 中，并允许将它们分类为潜在有用的诊断目的参数。
