Biology and Nutrition Department, ROQUETTE Frères, 62080 Lestrem, France.
Nutr Res Pract. 2010 Dec;4(6):470-6. doi: 10.4162/nrp.2010.4.6.470. Epub 2010 Dec 28.
The resistant dextrin NUTRIOSE®, developed from starch, is expected to act as a prebiotic. The aim of this study was to determine the effects of NUTRIOSE® on cecal parameters, short-chain fatty acid (SCFA) concentrations, and fecal excretion in rats. In an initial experiment, twenty-four male Fischer F344 rats were randomly assigned to one of the following four treatments for 14 days: G0 (control diet), G2.5 (control diet + 2.5% of dextrin), G5 (control diet + 5% of dextrin), and G10 (control diet + 10% of dextrin). After 14 days, total cecal weight, cecal content, and cecal wall weight were significantly increased in G5 and G10 compared to G0. At the same time, cecal pH was significantly lower in G10 compared to G0. Total SCFA concentration was significantly higher in G10 than in G5, G2.5, and G0, and significantly higher in G5 than in G0. Acetate, butyrate, and propionate concentrations were significantly increased in G5 and G10 compared to the controls. In a second trial based on a similar design, eighteen male Fischer F344 rats were treated with a control diet supplemented with 5% of dextrin or 5% of fructo-oligosaccharide. The results obtained with NUTRIOSE® were similar to those obtained with the fructo-oligosaccharide. In a third experiment, two groups of 5 Fischer F344 rats were orally treated with 100 and 1,000 mg/kg NUTRIOSE®, respectively, and from 18% to 25% of the dextrin was excreted in the feces. The results of these three studies show that the consumption of NUTRIOSE®, by its effects on total cecal weight, cecal content, cecal wall weight, pH, and SCFA production, could induce healthy benefits since these effects are reported to be prebiotic effects.
抗性糊精 NUTRIOSE® 是由淀粉制成的，有望作为一种益生元。本研究旨在确定 NUTRIOSE® 对大鼠盲肠参数、短链脂肪酸（SCFA）浓度和粪便排泄的影响。在初步试验中，将 24 只雄性 Fischer F344 大鼠随机分为以下四组，每组 6 只，分别喂食 14 天：G0（对照饮食）、G2.5（对照饮食+2.5%糊精）、G5（对照饮食+5%糊精）和 G10（对照饮食+10%糊精）。14 天后，G5 和 G10 的总盲肠重量、盲肠内容物和盲肠壁重量均显著高于 G0。同时，G10 的盲肠 pH 显著低于 G0。G10 的总 SCFA 浓度显著高于 G5、G2.5 和 G0，G5 也显著高于 G0。G5 和 G10 的乙酸盐、丁酸盐和丙酸盐浓度均显著高于对照组。在基于类似设计的第二次试验中，将 18 只雄性 Fischer F344 大鼠用对照饮食补充 5%的糊精或 5%的低聚果糖处理。用 NUTRIOSE® 得到的结果与用低聚果糖得到的结果相似。在第三次试验中，两组 5 只 Fischer F344 大鼠分别经口给予 100 和 1000 mg/kg NUTRIOSE®，其中 18%至 25%的糊精从粪便中排出。这三项研究的结果表明，由于 NUTRIOSE® 对总盲肠重量、盲肠内容物、盲肠壁重量、pH 值和 SCFA 产生的影响，其消耗可能会带来健康益处，因为这些影响被报道为益生元作用。
