van den Heuvel Ellen G H M, Wils Daniel, Pasman Wilrike J, Saniez Marie-Hélène, Kardinaal Alwine F M
Dept. of Physiological Sciences, TNO Nutrition and Food Research Business Unit Physiological Sciences, P. O. Box 360, 3700 AJ Zeist, The Netherlands.
Eur J Nutr. 2005 Oct;44(7):445-51. doi: 10.1007/s00394-005-0552-0. Epub 2005 Feb 9.
It is well documented that fermentation of carbohydrates that escape digestion exert several effects supposed to be beneficial for (colonic) health, including an increase in stool volume, a shorter intestinal transit time, production of short chain fatty acids and a decrease of colonic pH (Kritchevsky 1988). NUTRIOSE FB is a dextrin that is not completely hydrolysed and absorbed in the small intestine, due to many alpha-1.6 linkages and the presence of non-digestible glucoside linkages (e. g. alpha-1.2 and alpha-1.3). To be beneficial for 'colonic' health effective NUTRIOSE FB must reach the cecum in some form.
To estimate how much non digested NUTRIOSE FB is fermented and to determine the fibre-like effect of the wheat dextrin NUTRIOSE((R))FB by analysing enzymatic activity in faeces.
In a randomized, double-blind,multiple dose, placebo-controlled, combined cross-over and parallel trial, 20 healthy men (age 31.7 +/- 9.1 yrs; BMI 24.5 +/- 2.9 kg.m(-2) received different treatments. One group of ten subjects consumed on top of their diet 10, 30 and 60 g daily of NUTRIOSE FB or maltodextrin (placebo). The other group of 10 subjects consumed 15, 45 and 80 g daily. Each dose was consumed for 7 days. On the last two days of each of the 7-day period, faeces were collected in which the enzymatic activity and NUTRIOSE FB residue were analysed.
As expected, the faecal residue of NUTRIOSE FB non-linearly increased with the dose of NUTRIOSE FB to approximately 13% of 80 g/d. Compared with the placebo, 30, 45, 60 and 80 g/d of NUTRIOSE FB increased the concentration of alpha-glucosidase significantly. All daily doses of NUTRIOSE FB (10 g/d to 80 g/d) led to significant changes in concentration of beta-glucosidase.
The small amount of the residue of NUTRIOSE FB in the faeces suggests that approximately 87% or more of NUTRIOSE FB is digested or fermented in the gastrointestinal tract. Fermentation of NUTRIOSE FB led to an increased faecal concentration of alpha- and beta-glucosidase.
有充分记录表明，未被消化的碳水化合物发酵会产生多种对（结肠）健康有益的作用，包括粪便体积增加、肠道转运时间缩短、短链脂肪酸生成以及结肠pH值降低（Kritchevsky，1988年）。NUTRIOSE FB是一种糊精，由于存在许多α-1,6键和不可消化的糖苷键（如α-1,2和α-1,3），它在小肠中不会被完全水解和吸收。为了对“结肠”健康有益，有效的NUTRIOSE FB必须以某种形式到达盲肠。
通过分析粪便中的酶活性，估算未消化的NUTRIOSE FB有多少被发酵，并确定小麦糊精NUTRIOSE((R))FB的类纤维效应。
在一项随机、双盲、多剂量、安慰剂对照、交叉与平行试验相结合的研究中，20名健康男性（年龄31.7±9.1岁；体重指数24.5±2.9kg·m⁻²）接受了不同治疗。一组10名受试者在日常饮食基础上，每天分别摄入10克、30克和60克NUTRIOSE FB或麦芽糖糊精（安慰剂）。另一组10名受试者每天分别摄入15克、45克和80克。每个剂量持续摄入7天。在每个7天周期的最后两天，收集粪便并分析其中的酶活性和NUTRIOSE FB残留量。
正如预期的那样，NUTRIOSE FB的粪便残留量随其剂量呈非线性增加，在80克/天的剂量下约为13%。与安慰剂相比，每天30克、45克、60克和80克的NUTRIOSE FB显著提高了α-葡萄糖苷酶的浓度。所有NUTRIOSE FB的每日剂量（10克/天至80克/天）均导致β-葡萄糖苷酶浓度发生显著变化。
粪便中NUTRIOSE FB的残留量较少，这表明约87%或更多的NUTRIOSE FB在胃肠道中被消化或发酵。NUTRIOSE FB的发酵导致粪便中α-和β-葡萄糖苷酶浓度增加。
