Friedman M J
J Protozool. 1979 May;26(2):195-9. doi: 10.1111/j.1550-7408.1979.tb02760.x.
The process by which malaria parasites are killed in sickled erythrocytes was studied by electron microscopy. In vitro cultures of Plasmodium falciparum in sickle cell hemoglobin (HbS) homozygous (SS) and heterozygous (SA) red cells were deoxygenated for up to 6 h and fixed under anaerobic conditions. Parasites in SS cells appeared to be disrupted by intrusions of needle-like deoxyHbS aggregates; disintegration of cytoplasm and membranes followed. In SA red cells, the parasites were generally not disrupted. Instead, extensive vacuolization occurred, a sign of metabolic inhibition. The resistance of HbS gene carriers to malaria results partly from these causes of intracellular parasite death.
通过电子显微镜研究了疟原虫在镰状红细胞中被杀死的过程。将恶性疟原虫在镰状细胞血红蛋白（HbS）纯合子（SS）和杂合子（SA）红细胞中的体外培养物进行长达6小时的脱氧处理，并在厌氧条件下固定。SS细胞中的疟原虫似乎因针状脱氧HbS聚集体的侵入而被破坏；随后细胞质和细胞膜解体。在SA红细胞中，疟原虫通常不会被破坏。相反，出现了广泛的空泡化，这是代谢抑制的迹象。HbS基因携带者对疟疾的抗性部分源于这些导致细胞内寄生虫死亡的原因。
