Pasvol G
Trans R Soc Trop Med Hyg. 1980;74(6):701-5. doi: 10.1016/0035-9203(80)90182-0.
The mechanism whereby heterozygous carriers of the sickle cell gene are protected against fatal malarial infections due to Plasmodium falciparum has been examined in a short term in vitro cultivation system. The results have shown that both parasite invasion of red cells and parasite growth within red cells containing sickle haemoglobin (Hb-S) is restricted, but only under conditions of low (5%) oxygen tensions. To bring this about, the cells containing Hb-S need not sickle. Furthermore the growth retardation observed in the presence of Hb-S was also found to apply to the mature forms of the parasite. These findings offer a plausible mechanism for the protection of sickle heterozygotes against falciparum malaria.
镰状细胞基因杂合子携带者免受恶性疟原虫所致致命性疟疾感染的机制已在一个短期体外培养系统中进行了研究。结果表明，疟原虫对红细胞的侵袭以及在含有镰状血红蛋白（Hb-S）的红细胞内的生长均受到限制，但仅在低（5%）氧张力条件下如此。要实现这一点，含有Hb-S的细胞并不需要发生镰变。此外，在Hb-S存在的情况下观察到的生长迟缓现象也被发现适用于疟原虫的成熟形式。这些发现为镰状细胞杂合子免受恶性疟疾感染提供了一个合理的机制。
