Liang Cheng, Wang Ping, Li Mengzhen, Li Rong, Lai Keng Po, Chen Jian
Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, China.
Key Laboratory of Environmental Pollution and Integrative Omics, Guilin Medical University, Education Department of Guangxi Zhuang Autonomous Region, Guilin, China.
Heliyon. 2024 Mar 27;10(7):e28616. doi: 10.1016/j.heliyon.2024.e28616. eCollection 2024 Apr 15.
The incidence of skin-related neoplasms has generally increased in recent years. Melanoma arises from malignant mutations in melanocytes in the basal layer of the epidermis and is a fatal skin cancer that seriously threatens human health. Isoflavones are polyphenolic compounds widely present in legumes and have drawn scientists' attention, because they have good efficacy against a variety of cancers, including melanoma, without significant toxic side effects and resistance. In this review article, we summarize the research progress of isoflavones in melanoma, including anti-melanoma roles and mechanisms of isoflavones via inhibition of tyrosinase activity, melanogenesis, melanoma cell growth, invasion of melanoma cells, and induction of apoptosis in melanoma cells. This information is important for the prevention, clinical treatment, and prognosis and survival of melanoma.
近年来，皮肤相关肿瘤的发病率总体呈上升趋势。黑色素瘤起源于表皮基底层黑素细胞的恶性突变，是一种严重威胁人类健康的致命性皮肤癌。异黄酮是广泛存在于豆类中的多酚类化合物，因其对包括黑色素瘤在内的多种癌症具有良好疗效，且无明显毒副作用和耐药性，而受到科学家的关注。在这篇综述文章中，我们总结了异黄酮在黑色素瘤方面的研究进展，包括异黄酮通过抑制酪氨酸酶活性、黑色素生成、黑色素瘤细胞生长以及黑色素瘤细胞侵袭和诱导黑色素瘤细胞凋亡等发挥的抗黑色素瘤作用及机制。这些信息对于黑色素瘤的预防、临床治疗以及预后和生存具有重要意义。
