探讨区域性脂肪分布与心房颤动风险的关联：一项综合队列研究。
Exploring the association between regional fat distribution and atrial fibrillation risks: a comprehensive cohort study.
机构信息
Department of Cardiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Department of Emergency Medicine, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
出版信息
Front Endocrinol (Lausanne). 2024 Mar 22;15:1367653. doi: 10.3389/fendo.2024.1367653. eCollection 2024.
BACKGROUND
The contribution of total fat mass and regional fat distribution to the risk of AF has rarely been studied.
METHODS
This prospective cohort study(N=494,063) evaluated the association of total fat mass measured by fat percentage (FP) and regional fat measured by arm fat percentage (AFP), trunk fat percentage (TFP), and leg fat percentage (LFP) with incident AF. A subgroup (N = 25,581) underwent MRI, which allowed us to further assess whether visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (ASAT) of the trunk fat exert different effects on AF incidence.
RESULTS
Over, a median 12.9 ± 1.86 years of follow-up, 29,658 participants (cumulative rate: 6.0%) developed AF. Each 1-standard deviation (SD) increase in LFP was associated with a 16% lower risk of AF (HR: 0.84, 95% CI: 0.82, 0.85). The association between FP and AF was weaker than that between LFP and AF (HR: 0.90, 95% CI: 0.89, 0.92). AFP and TFP only had a marginal association with a lower incidence of AF. Both the VAT and ASAT showed a U-shaped relationship with incident AF.
CONCLUSIONS
Fat mass, mainly leg fat mass, was associated with a lower risk of AF. ASAT did not exert protective effects.
背景
总脂肪量和局部脂肪分布对房颤风险的影响很少被研究。
方法
本前瞻性队列研究（N=494,063）评估了总脂肪量（通过体脂率[FP]测量）和局部脂肪（通过臂脂率[AFP]、躯干脂肪率[TFP]和腿脂率[LFP]测量）与房颤发生的相关性。亚组（N=25,581）接受了 MRI 检查，这使我们能够进一步评估躯干脂肪的内脏脂肪组织（VAT）和腹部皮下脂肪组织（ASAT）对房颤发生率的影响是否不同。
结果
在中位 12.9±1.86 年的随访中，29,658 名参与者（累积发生率：6.0%）发生了房颤。LFP 每增加 1 个标准差（SD），房颤风险降低 16%（HR：0.84，95%CI：0.82，0.85）。FP 与房颤的相关性比 LFP 与房颤的相关性弱（HR：0.90，95%CI：0.89，0.92）。AFP 和 TFP 与房颤发生率仅呈弱相关。VAT 和 ASAT 与房颤的发生均呈 U 型关系。
结论
脂肪量，主要是腿部脂肪量，与房颤风险降低相关。ASAT 没有发挥保护作用。
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