体脂肪、体脂肪分布、去脂体重与心房颤动和房扑。一项丹麦队列研究。
Body fat, body fat distribution, lean body mass and atrial fibrillation and flutter. A Danish cohort study.
机构信息
Department of Medicine, Silkeborg Hospital & Institute of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.
出版信息
Obesity (Silver Spring). 2014 Jun;22(6):1546-52. doi: 10.1002/oby.20706. Epub 2014 Feb 18.
OBJECTIVE
It is recognized that higher height and weight are associated with higher risk of atrial fibrillation or flutter (AF) but it is unclear whether risk of AF is related to body fat, body fat location, or lean body mass.
METHODS
This article reports the Danish population-based prospective cohort Diet, Cancer and Health study conducted among 55,273 men and women 50-64 years of age at recruitment. The associations between bioelectrical impedance derived measures of body composition and combinations of anthropometric measures of body fat distribution and risk of an incident record of AF in the Danish Registry of Patients were investigated.
RESULTS
During follow-up (median 13.5 years) AF developed in 1,669 men and 912 women. Higher body fat at any measured location was associated with higher risk of AF. The adjusted hazard ratio (HR) per 1 sex-specific standard deviation (SD) increment in body fat mass was 1.29 (95% confidence interval [CI], 1.24-1.33). Higher lean body mass was also associated with a higher risk of AF. The adjusted HR for 1 sex-specific SD increment was 1.40 (95% CI, 1.35-1.45).
CONCLUSION
Higher body fat and higher lean body mass were both associated with higher risk of AF.
目的
人们认识到，身高和体重较高与心房颤动或心房扑动（AF）的风险增加有关，但尚不清楚 AF 的风险是否与体脂肪、体脂肪位置或瘦体重有关。
方法
本文报道了丹麦基于人群的前瞻性队列饮食、癌症和健康研究，该研究在招募时纳入了 55273 名年龄在 50-64 岁的男性和女性。研究了生物电阻抗法测量的身体成分指标与人体脂肪分布的人体测量指标组合与丹麦患者登记处记录的 AF 事件风险之间的关系。
结果
在随访期间（中位随访 13.5 年），1669 名男性和 912 名女性发生了 AF。任何测量部位的体脂肪越高，AF 的风险就越高。每增加一个特定性别的标准偏差（SD）体脂肪质量，校正后的危害比（HR）为 1.29（95%置信区间[CI]，1.24-1.33）。较高的瘦体重也与 AF 的风险增加有关。每增加一个特定性别的 SD，校正后的 HR 为 1.40（95%CI，1.35-1.45）。
结论
较高的体脂肪和较高的瘦体重都与 AF 的风险增加有关。
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