Wang Junke, Guo Fenglian, Zhang Jingjing, Chao Jie
State Key Laboratory of Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts and Telecommunications, 9 Wenyuan Road, Nanjing 210023, China.
Portland Institute, Nanjing University of Posts and Telecommunications, Nanjing 210023, China.
Chem Commun (Camb). 2024 Apr 23;60(34):4609-4612. doi: 10.1039/d4cc00996g.
A novel ECL immunosensor was developed for simultaneous determination of multiplex bladder cancer markers. DNA tetrahedra act as capture probes, while Ru-MOF@AuNPs and AuAgNCs act as signal reporters, yielding well-separated signals reflecting NUMA1 and CFHR1 concentrations. This strategy offers a new platform for clinical immunoassays, enabling simultaneous multiplex tumor marker detection.
一种新型的电化学发光免疫传感器被开发用于同时测定多种膀胱癌标志物。DNA四面体作为捕获探针，而钌基金属有机框架@金纳米粒子（Ru-MOF@AuNPs）和金银纳米簇（AuAgNCs）作为信号报告分子，产生反映核有丝分裂器蛋白1（NUMA1）和补体因子H相关蛋白1（CFHR1）浓度的分离良好的信号。该策略为临床免疫分析提供了一个新平台，能够同时进行多种肿瘤标志物检测。
