抗抑郁药与内源性阿片肽系统。
Antidepressants and endogenous opioid peptide systems.
作者信息
Przewłocki R, Lasoń W, Majeed N H, Przewłocka B
出版信息
Neuropeptides. 1985 Feb;5(4-6):575-8. doi: 10.1016/0143-4179(85)90083-6.
The influence of antidepressants on the brain and pituitary content of immunoreactive beta-endorphin (ir-beta E) and dynorphin (ir-DYN) was studied in rats. Chronic administration of the first and second generation antidepressants imipramine, citalopram and rolipram, and of the antidepressant neuroleptics levomepromazine and chlorprothixene elevated the level of ir-beta E in the hypothalamus. Imipramine and levomepromazine also increased the level of ir-DYN in this tissue. Imipramine administered chronically potentiated stress-induced as well as morphine analgesia. The results obtained suggest that chronic antidepressants enhance the brain opioid system activity and increase the sensitivity of opiate receptors.
研究了抗抑郁药对大鼠大脑和垂体中免疫反应性β-内啡肽（ir-βE）和强啡肽（ir-DYN）含量的影响。第一代和第二代抗抑郁药丙咪嗪、西酞普兰和咯利普兰，以及抗抑郁性抗精神病药左美丙嗪和氯普噻吨的长期给药可提高下丘脑中ir-βE的水平。丙咪嗪和左美丙嗪也可增加该组织中ir-DYN的水平。长期给予丙咪嗪可增强应激诱导的镇痛以及吗啡镇痛作用。所得结果表明，长期使用抗抑郁药可增强脑阿片系统活性并提高阿片受体的敏感性。
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