长期给予抗抑郁药后大鼠皮质[3H]纳洛酮结合位点密度增加。
Increase in rat cortical [3H]naloxone binding site density after chronic administration of antidepressant agents.
作者信息
Antkiewicz-Michaluk L, Rokosz-Pelc A, Vetulani J
出版信息
Eur J Pharmacol. 1984 Jun 15;102(1):179-81. doi: 10.1016/0014-2999(84)90355-8.
PMID:6090155
Abstract
Given chronically, the first and second generation antidepressants imipramine and citalopram, and antidepressant neuroleptics levomepromazine and chlorprothixene, elevated moderately but significantly (by 15-30%) the density of [3H]naloxone binding sites in rat cerebral cortical membranes. There were only small non-significant changes in Kd values.
摘要
长期给予第一代和第二代抗抑郁药丙咪嗪和西酞普兰，以及抗抑郁性抗精神病药左美丙嗪和氯普噻吨，可使大鼠大脑皮质膜中[3H]纳洛酮结合位点的密度适度但显著升高（升高15%-30%）。解离常数（Kd）值仅有微小的、不显著的变化。
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