低强度血流限制训练对非创伤性膝关节疾病的影响：一项系统评价和荟萃分析
Effect of Low-Intensity Bloodflow Restriction Training on Nontraumatic Knee Joint Conditions: A Systematic Review and Meta-analysis.
作者信息
Peng PeiQiang, Lu Yuming, Wang YueTing, Sui Xin, Yang Zhenning, Xu Haiyan, Zhang Shuang
机构信息
School of Nursing, Jilin University, Chaoyang District, Changchun, China.
Department of Orthopedics, Lequn Branch, The First Hospital of Jilin University, District, Changchun, China.
出版信息
Sports Health. 2025 Mar;17(2):226-235. doi: 10.1177/19417381241235147. Epub 2024 Apr 8.
CONTEXT
Nontraumatic knee conditions are common in clinical practice. Existing pharmaceutical and immobilization approaches provide limited pain relief and functional enhancement. Low-intensity bloodflow restriction training (LI-BFRT) is being investigated as a nonpharmacological alternative; however, its efficacy is uncertain.
OBJECTIVE
To assess the effectiveness of LI-BFRT for nontraumatic knee conditions and compare it with high-intensity resistance training (HI-RT) and low-intensity resistance training (LI-RT).
DATA SOURCES
PubMed, EBSCO, Science Direct, Cochrane Library, China Knowledge Infrastructure, Wanfang Data, and VIP databases were searched until May 30, 2023.
STUDY SELECTION
Original randomized controlled trials involving nontraumatic knee joint conditions with interventions consisting mainly of LI-BFRT, HI-RT, or LI-RT. The results assessed mainly pain and muscle performance.
STUDY DESIGN
Systematic review and meta-analysis.
LEVEL OF EVIDENCE
Level 1.
DATA EXTRACTION
Sample characteristics, study design, country, disease, groups, evaluation time, duration, and outcomes were extracted.
RESULTS
A total of 13 randomized controlled trials were included in the systematic review. Compared with pretreatment, LI-BFRT significantly alleviated pain (weighted standardized mean difference [SMD], -1.33; 95% CI, -1.62 to -1.05), with better additional effects on hip muscle training (SMD, -3.14; 95% CI, -4.07 to -2.75). Compared with LI-RT, LI-BFRT significantly relieved pain in male patients (SMD, -1.47; 95% CI, -1.92 to -1.01). LI-BFRT significantly increased quadriceps cross-sectional area (SMD, 0.53; 95% CI, 0.27-0.78), knee extension strength (SMD, 0.84; 95% CI, 0.48-1.2), and leg press strength (SMD, 0.64; 95% CI, 0.34-0.94) compared with pretreatment. Its effects were superior to those of LI-RT and similar to those of HI-RT. However, sex differences in muscle strength improvement were observed.
CONCLUSION
In patients with nontraumatic knee joint conditions, LI-BFRT effectively alleviated pain, increased muscle cross-sectional area, and enhanced muscle strength. LI-BFRT showed pain relief comparable with that of LI-RT while surpassing LI-RT in muscle growth and strength improvement.
背景
非创伤性膝关节疾病在临床实践中很常见。现有的药物治疗和固定方法在缓解疼痛和改善功能方面效果有限。低强度血流限制训练（LI-BFRT）作为一种非药物替代方法正在进行研究；然而，其疗效尚不确定。
目的
评估LI-BFRT对非创伤性膝关节疾病的有效性，并将其与高强度阻力训练（HI-RT）和低强度阻力训练（LI-RT）进行比较。
数据来源
检索了PubMed、EBSCO、Science Direct、Cochrane图书馆、中国知网、万方数据和维普数据库，检索截至2023年5月30日。
研究选择
涉及非创伤性膝关节疾病的原始随机对照试验，干预措施主要包括LI-BFRT、HI-RT或LI-RT。结果主要评估疼痛和肌肉性能。
研究设计
系统评价和荟萃分析。
证据水平
1级。
数据提取
提取样本特征、研究设计、国家、疾病、分组、评估时间、持续时间和结果。
结果
系统评价共纳入13项随机对照试验。与治疗前相比，LI-BFRT显著减轻疼痛（加权标准化均数差[SMD]，-1.33；95%CI，-1.62至-1.05），对髋部肌肉训练有更好的附加效果（SMD，-3.14；95%CI，-4.07至-2.75）。与LI-RT相比，LI-BFRT在男性患者中显著缓解疼痛（SMD，-1.47；95%CI，-1.92至-1.01）。与治疗前相比，LI-BFRT显著增加股四头肌横截面积（SMD，0.53；95%CI，0.27-0.78）、膝关节伸展力量（SMD，0.84；95%CI，0.48-1.2）和腿举力量（SMD，0.64；95%CI，0.34-0.94）。其效果优于LI-RT，与HI-RT相似。然而，观察到肌肉力量改善存在性别差异。
结论
在非创伤性膝关节疾病患者中，LI-BFRT有效缓解疼痛，增加肌肉横截面积，增强肌肉力量。LI-BFRT在缓解疼痛方面与LI-RT相当，而在肌肉生长和力量改善方面超过LI-RT。
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