Mheissen Samer
Syrian Board in Orthodontics, Specialist Orthodontist, Private Practice, Damascus, Syria.
J Orthod. 2024 Apr 8:14653125241245140. doi: 10.1177/14653125241245140.
Meta-analysis is a statistical method used in systematic reviews to provide a quantitative estimate of the effect. However, including very few studies and participants may increase the risk of spurious findings. Trial sequential analysis (TSA) has been introduced to enhance the robustness of meta-analysis. TSA is a cumulative meta-analysis method that weighs type I and II errors while estimating the effect. The application of TSA can lead to a more accurate estimation of the clinical effectiveness of the intervention. The aim of the present paper was to introduce the TSA to orthodontic clinicians and researchers using continuous data from an orthodontic systematic review.
Meta分析是一种用于系统评价的统计方法，旨在对效应进行定量估计。然而，纳入的研究和参与者数量过少可能会增加得出虚假结果的风险。试验序贯分析（TSA）已被引入以增强Meta分析的稳健性。TSA是一种累积Meta分析方法，在估计效应时权衡I型和II型错误。TSA的应用可以更准确地估计干预措施的临床疗效。本文的目的是通过正畸系统评价中的连续数据，向正畸临床医生和研究人员介绍TSA。
