“无方式”酶促S-亚硝基化调控胰岛素病理生理学。
'NO-how' enzymatic S-nitrosylation controls insulin pathophysiology.
作者信息
Filomeni Giuseppe
机构信息
Redox Biology, Danish Cancer Institute, Strandboulevarden 49, 2100, Copenhagen, Denmark; Department of Biology, Tor Vergata University, Via della Ricerca Scientifica, 00133, Rome, Italy.
出版信息
Trends Endocrinol Metab. 2024 Feb 28. doi: 10.1016/j.tem.2024.02.010.
Whether S-nitrosylation is the result of an unselective chemical process or enzymatically driven has been debated for years. A recent study by Zhou et al. identifies and characterizes the first S-nitroso-CoA (SNO-CoA)-assisted nitrosylase (SCAN) that catalyzes protein S-nitrosylation in mammals, including insulin receptor (INSR)/insulin receptor substrate 1 (IRS1), with implications for human metabolism.
S-亚硝基化是由非选择性化学过程还是酶促驱动所致，多年来一直存在争议。周等人最近的一项研究鉴定并表征了首个S-亚硝基辅酶A（SNO-CoA）辅助的亚硝基化酶（SCAN），该酶在哺乳动物中催化蛋白质S-亚硝基化，包括胰岛素受体（INSR）/胰岛素受体底物1（IRS1），对人类新陈代谢具有重要意义。
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