Department of PediatricHematology/Oncology, Akron Children's Hospital, Akron, Ohio, USA.
Division of PediatricHematology/Oncology, Nationwide Children's Hospital, Columbus, Ohio, USA.
Pediatr Hematol Oncol. 2024 Aug;41(5):336-345. doi: 10.1080/08880018.2024.2337627. Epub 2024 Apr 8.
Current studies describing younger children with Hodgkin lymphoma are limited by geographical region, small sample sizes and variable age groups. Although published data is lacking, there appears to be a trend toward a higher male to female ratio and a higher proportion of mixed cellularity subtype when compared to older cohorts. We performed a retrospective multicenter study utilizing the Pediatric Health Information System® database to evaluate patients aged 0-39 years with Hodgkin lymphoma. We identified 3,034 unique patients who met inclusion criteria. Younger age groups had a larger proportion of males, Hispanic/Latino ethnicity, and mixed cellularity subtype. Treatment-related complications, including mucositis, pain, bacterial infections, and thrombosis, were documented more frequently in older cohorts. We also found significant age-related differences in medical management. This study is the largest study evaluating age-related differences in patients with Hodgkin lymphomaand the first study to evaluate for differences in complicationsand supportive care management.
目前描述霍奇金淋巴瘤幼儿患者的研究受到地域范围、样本量小和年龄组变化的限制。尽管缺乏已发表的数据，但与年龄较大的患者队列相比，似乎存在男性与女性比例更高和混合细胞亚型比例更高的趋势。我们进行了一项回顾性多中心研究，利用儿科健康信息系统®数据库评估年龄在 0-39 岁的霍奇金淋巴瘤患者。我们确定了 3034 名符合纳入标准的独特患者。年龄较小的组中男性、西班牙裔/拉丁裔种族和混合细胞亚型的比例更大。在年龄较大的组中，记录了更多与治疗相关的并发症，包括黏膜炎、疼痛、细菌感染和血栓形成。我们还发现了与医疗管理相关的显著年龄相关差异。这项研究是评估霍奇金淋巴瘤患者年龄相关差异的最大研究，也是第一项评估并发症和支持性护理管理差异的研究。
