Department of Psychiatry and Neuroscience|CCM, NeuroCure Clinical Research Center, Berlin Institute of Health CCM, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
German Center for Mental Health (DZPG), Berlin-Potsdam.
Addict Biol. 2024 Apr;29(4):e13379. doi: 10.1111/adb.13379.
One of the leading drug addiction theories states that habits and the underlying neural process of a ventral to dorsal striatal shift are the building blocks of compulsive drug-seeking behaviour and that compulsion is the maladaptive persistence of responding despite adverse consequences. Here we discuss that compulsive behaviour as defined primarily from the perspective of animal experimentation falls short of the clinical phenomena and their neurobiological correlates. Thus for the human condition, the concept of compulsive habbits should be critically addressed and potentially revised.
一种主要的成瘾理论认为，习惯和腹侧至背侧纹状体转移的潜在神经过程是强迫性觅药行为的基础，而强迫是尽管有不利后果仍持续反应的适应不良。在这里，我们讨论了主要从动物实验角度定义的强迫行为与临床现象及其神经生物学相关性之间的差距。因此，对于人类状况，应该批判性地处理和可能修改强迫习惯的概念。
