From the Environmental Health Sciences Division, School of Public Health (de la Rosa, Le), University of California, Berkeley, Berkeley, California; Division of Pulmonary and Critical Care Medicine, Department of Medicine (de la Rosa, Ye, Thakur), University of California, San Francisco; Western States Pediatric Environmental Health Specialty Unit (Holm); Departments of Psychiatry and Behavioral Science (Bush), Pediatrics (Bush, Long), and Family and Community Medicine (Hessler), University of California, San Francisco; Center for Youth Wellness (Koita, Bucci); and UCSF Benioff Children's Hospital Oakland (Long), San Francisco, California.
Psychosom Med. 2024 Jun 1;86(5):422-430. doi: 10.1097/PSY.0000000000001276. Epub 2024 Apr 17.
Examine the independent associations and interaction between early-life adversity and residential ambient air pollution exposure on relative buccal telomere length (rBTL).
Experiences of abuse, neglect, household challenges, and related life events were identified in a cross-sectional sample of children aged 1 to 11 years ( n = 197) using the 17-item Pediatric ACEs and Related Life Event Screener (PEARLS) tool. The PEARLS tool was analyzed both as a total score and across established domains (Maltreatment, Household Challenges, and Social Context). Ground-level fine particulate matter (PM 2.5 ) concentrations were matched to residential locations for the 1 and 12 months before biospecimen collection. We used multivariable linear regression models to examine for independent associations between continuous PM 2.5 exposure and PEARLS score/domains with rBTL. In addition, effect modification by PEARLS scores and domains on associations between PM 2.5 exposure and rBTL was examined.
Study participants were 47% girls, with mean (standard deviation) age of 5.9 (3.4) years, median reported PEARLS score of 2 (interquartile range [IQR], 4), median 12-month prior PM 2.5 concentrations of 11.8 μg/m 3 (IQR, 2.7 μg/m 3 ), median 1-month prior PM 2.5 concentrations of 10.9 μg/m 3 (IQR, 5.8 μg/m 3 ), and rBTL of 0.1 (IQR, 0.03). Mean 12-month prior PM 2.5 exposure was inversely associated with rBTL ( β = -0.02, 95% confidence interval = -0.04 to -0.01). Although reported PEARLS scores and domains were not independently associated with rBTL, we observed a greater decrement in rBTL with increment of average annual PM 2.5 as reported Social Context domain items increased ( p -interaction < .05).
Our results suggest that adverse Social Context factors may accelerate the association between chronic PM 2.5 exposure on telomere shortening during childhood.
探讨儿童早期逆境经历与居住环境大气污染暴露对相对颊部端粒长度（rBTL）的独立关联和交互作用。
采用 17 项儿科 ACEs 和相关生活事件筛查工具（PEARLS），对 1 至 11 岁儿童的横断面样本（n=197）进行虐待、忽视、家庭挑战和相关生活事件的识别。PEARLS 工具既作为总分，也作为既定领域（虐待、家庭挑战和社会环境）进行分析。在生物样本采集前 1 个月和 12 个月，将地面细颗粒物（PM 2.5 ）浓度与居住地点相匹配。我们使用多变量线性回归模型，检查 PM 2.5 暴露的连续测量值与 PEARLS 评分/领域与 rBTL 之间的独立关联。此外，还检查了 PEARLS 评分和领域对 PM 2.5 暴露与 rBTL 之间关联的修饰作用。
研究参与者中 47%为女孩，平均（标准差）年龄为 5.9（3.4）岁，中位数报告的 PEARLS 评分为 2（四分位距[IQR]，4），中位数 12 个月前 PM 2.5 浓度为 11.8μg/m 3 （IQR，2.7μg/m 3 ），中位数 1 个月前 PM 2.5 浓度为 10.9μg/m 3 （IQR，5.8μg/m 3 ），rBTL 为 0.1（IQR，0.03）。12 个月前 PM 2.5 暴露均值与 rBTL 呈负相关（β=-0.02，95%置信区间=-0.04 至-0.01）。尽管报告的 PEARLS 评分和领域与 rBTL 无关，但我们观察到随着社会环境领域项目的增加，平均每年 PM 2.5 报告的增加与 rBTL 下降幅度更大（p 交互作用<.05）。
我们的结果表明，不利的社会环境因素可能会加速儿童期慢性 PM 2.5 暴露与端粒缩短之间的关联。
