Awindaogo Felix, Acheamfour-Akowuah Emmanuel, Doku Alfred, Kokuro Collins, Agyekum Francis, Owusu Isaac Kofi
Korle-Bu Teaching Hospital, Accra, Ghana.
Directorate of Medicine Kumasi, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
JMIR Res Protoc. 2024 Apr 8;13:e52616. doi: 10.2196/52616.
Heart failure (HF) is a leading cause of morbidity and mortality globally, with a high disease burden. The prevalence of HF in Ghana is increasing rapidly, but epidemiological profiles, treatment patterns, and survival data are scarce. The national capacity to diagnose and manage HF appropriately is also limited. To address the growing epidemic of HF, it is crucial to recognize the epidemiological characteristics and medium-term outcomes of HF in Ghana and improve the capability to identify and manage HF promptly and effectively at all levels of care.
This study aims to determine the epidemiological characteristics and medium-term HF outcomes in Ghana.
We conducted a prospective, multicenter, multilevel cross-sectional observational study of patients with HF from January to December 2023. Approximately 5000 patients presenting with HF to 9 hospitals, including teaching, regional, and municipal hospitals, will be recruited and evaluated according to a standardized protocol, including the use of an echocardiogram and an N-terminal pro-brain natriuretic peptide (NT-proBNP) test. Guideline-directed medical treatment of HF will be initiated for 6 months, and the medium-term outcomes of interventions, including rehospitalization and mortality, will be assessed. Patient data will be collated into a HF registry for continuous assessment and monitoring.
This intervention will generate the necessary information on the etiology of HF, clinical presentations, the diagnostic yield of various tools, and management outcomes. In addition, it will build the necessary capacity and support for HF management in Ghana. As of July 30, 2023, the training and onboarding of all 9 centers had been completed. Preliminary analyses will be conducted by the end of the second quarter of 2024, and results are expected to be publicly available by the middle of 2024.
This study will provide the necessary data on HF, which will inform decisions on the prevention and management of HF and form the basis for future research.
ISRCTN Registry (United Kingdom) ISRCTN18216214; https:www.isrctn.com/ISRCTN18216214.
INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/52616.
心力衰竭（HF）是全球发病和死亡的主要原因，疾病负担沉重。加纳心力衰竭的患病率正在迅速上升，但流行病学特征、治疗模式和生存数据却很匮乏。加纳国家层面适当诊断和管理心力衰竭的能力也很有限。为应对日益严重的心力衰竭流行问题，认识加纳心力衰竭的流行病学特征和中期结局，并提高各级医疗保健机构及时有效识别和管理心力衰竭的能力至关重要。
本研究旨在确定加纳心力衰竭的流行病学特征和中期结局。
我们于2023年1月至12月对心力衰竭患者进行了一项前瞻性、多中心、多层次横断面观察性研究。将招募约5000名到9家医院（包括教学医院、地区医院和市立医院）就诊的心力衰竭患者，并根据标准化方案进行评估，包括使用超声心动图和N末端脑钠肽前体（NT-proBNP）检测。将启动为期6个月的心力衰竭指南指导药物治疗，并评估干预措施的中期结局，包括再住院率和死亡率。患者数据将整理到心力衰竭登记册中，以便持续评估和监测。
这项干预措施将生成有关心力衰竭病因、临床表现、各种工具的诊断率以及管理结局的必要信息。此外，它将为加纳的心力衰竭管理建立必要的能力并提供支持。截至2023年7月30日，所有9个中心的培训和入职工作均已完成。初步分析将于2024年第二季度末进行，预计结果将于2024年年中公开。
本研究将提供有关心力衰竭的必要数据，为心力衰竭的预防和管理决策提供依据，并为未来研究奠定基础。
ISRCTN注册库（英国）ISRCTN18216214；https:www.isrctn.com/ISRCTN18216214。
国际注册报告识别码（IRRID）：DERR1-10.2196/52616。
