Urogenital Sub-Committee and the Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Diseases (JAID) and the Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan; Department of Urology, Japan Organization of Occupational Health and Safety, Chugoku Rosai Hospital, Hiroshima, Japan.
Urogenital Sub-Committee and the Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Diseases (JAID) and the Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan; Department of Infection Control and Laboratory Medicine, Sapporo Medical University School of Medicine, Hokkaido, Japan.
J Infect Chemother. 2024 Jul;30(7):579-589. doi: 10.1016/j.jiac.2024.03.024. Epub 2024 Apr 6.
Antimicrobial susceptibility patterns of bacterial pathogens isolated from patients with complicated urinary tract infections were analyzed using the national surveillance data, comprising 793 bacterial strains from eight clinically relevant species.
Data were collected for the fourth national surveillance project from July 2020 to December 2021 by the Japanese Society of Chemotherapy, the Japanese Association for Infectious Disease, and the Japanese Society of Clinical Microbiology. Surveillance was supervised with the cooperation of 43 medical institutions throughout Japan.
Fluoroquinolone required a minimum inhibitory concentration (MIC) of 2-64 mg/L to inhibit the 330 tested Escherichia coli strains. The proportion of levofloxacin-resistant E. coli strains increased from 28.6% in 2008 to 29.6% in 2011, 38.5% in 2015, and 44.5% in 2021. The proportion of levofloxacin-resistant strains of Pseudomonas aeruginosa also increased from previous survey results, showing a continuing downward trend. Conversely, the proportion of levofloxacin-resistant strains of Enterococcus faecalis decreased relative to previous reports. Neither multidrug-resistant P. aeruginosa nor carbapenem-resistant Enterobacteriaceae were detected. For methicillin-resistant Staphylococcus aureus (MRSA), the proportion of vancomycin-susceptible strains (MIC of 2 μg/mL) decreased from 14.7% to 7.7%.
Bacterial strains that produced extended-spectrum β-lactamase included E. coli (82/330 strains, 24.8%), Klebsiella pneumoniae (11/68 strains, 16.2%), and Proteus mirabilis (4/26 strains, 15.4%). As compared to previous surveillance reports, these strains showed an increase in proportion over the years.
使用国家监测数据对来自复杂性尿路感染患者的细菌病原体的抗菌药物敏感性模式进行了分析，该数据包含来自 8 种临床相关种属的 793 株细菌。
该数据来自于 2020 年 7 月至 2021 年 12 月的第四次全国监测项目，由日本化疗学会、日本传染病学会和日本临床微生物学会收集。该监测在日本 43 家医疗机构的合作下进行监督。
氟喹诺酮类药物抑制 330 株测试的大肠埃希菌的最低抑菌浓度（MIC）需要 2-64mg/L。左氧氟沙星耐药大肠埃希菌的比例从 2008 年的 28.6%增加到 2011 年的 29.6%、2015 年的 38.5%和 2021 年的 44.5%。铜绿假单胞菌中左氧氟沙星耐药株的比例也高于之前的调查结果，呈持续下降趋势。相反，粪肠球菌中左氧氟沙星耐药株的比例较之前的报告有所下降。未检测到多药耐药铜绿假单胞菌或耐碳青霉烯类肠杆菌科细菌。对于耐甲氧西林金黄色葡萄球菌（MRSA），万古霉素敏感株（MIC 为 2μg/mL）的比例从 14.7%下降到 7.7%。
产生超广谱β-内酰胺酶的细菌包括大肠埃希菌（330 株中的 82 株，24.8%）、肺炎克雷伯菌（68 株中的 11 株，16.2%）和奇异变形杆菌（26 株中的 4 株，15.4%）。与之前的监测报告相比，这些菌株的比例多年来呈上升趋势。
