Chen Jianhua, Jin Liri, Lin Nan
Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing, 100730, China.
Neurol Sci. 2024 Sep;45(9):4539-4547. doi: 10.1007/s10072-024-07519-3. Epub 2024 Apr 8.
The aim of the study is to analyze microstate patterns in GLUT1-DS, both before and after the ketogenic diet (KD).
We conducted microstate analysis of a patient with GLUT-1 DS and 27 healthy controls. A systematic literature review and meta-analysis was done. We compared the parameters of the patients with those of healthy controls and the incorporating findings in literature.
The durations of the patient were notably shorter, and the occurrence rates were longer than those of healthy controls and incorporating findings from the review. After 10 months of KD, the patient's microstate durations exhibited an increase from 53.05 ms, 57.17 ms, 61.80 ms, and 49.49 ms to 60.53 ms, 63.27 ms, 71.11 ms, and 66.55 ms. The occurrence rates changed from 4.0774 Hz, 4.9462 Hz, 4.8006 Hz, and 4.0579 Hz to 3.3354 Hz, 3.7893 Hz, 3.5956 Hz, and 4.1672 Hz. In healthy controls, the durations of microstate class A, B, C, and D were 61.86 ms, 63.58 ms, 70.57 ms, and 72.00 ms, respectively.
Our findings suggest EEG microstates may be a promising biomarker for monitoring the effect of KD. Administration of KD may normalize the dysfunctional patterns of temporal parameters.
本研究旨在分析生酮饮食（KD）前后葡萄糖转运蛋白1缺陷综合征（GLUT1-DS）的微状态模式。
我们对1例GLUT-1 DS患者和27名健康对照者进行了微状态分析。进行了系统的文献综述和荟萃分析。我们将患者的参数与健康对照者的参数以及文献中的纳入研究结果进行了比较。
该患者的微状态持续时间明显短于健康对照者，且发生率高于健康对照者及综述中的纳入研究结果。KD治疗10个月后，患者的微状态持续时间从53.05毫秒、57.17毫秒、61.80毫秒和49.49毫秒增加到60.53毫秒、63.27毫秒、71.11毫秒和66.55毫秒。发生率从4.0774赫兹、4.9462赫兹、4.8006赫兹和4.0579赫兹变为3.3354赫兹、3.7893赫兹、3.5956赫兹和4.1672赫兹。在健康对照者中，A、B、C和D类微状态的持续时间分别为61.86毫秒、63.58毫秒、70.57毫秒和72.00毫秒。
我们的研究结果表明，脑电图微状态可能是监测KD疗效的一个有前景的生物标志物。KD治疗可能使时间参数的功能障碍模式正常化。
