亚胺培南/西司他丁：一家社区医院的总体经验

Imipenem/cilastatin: general experience in a community hospital.

作者信息

Iannini P B, Kunkel M J, Hilton E, Iannini G M

出版信息

Am J Med. 1985 Jun 7;78(6A):122-6. doi: 10.1016/0002-9343(85)90114-7.

Abstract

Imipenem/cilastatin is a new carbapenem antibiotic with broad spectrum antimicrobial activity. Forty two patients with infections of various types, including skin and soft tissue, respiratory tract, bone and joint, and urinary tract, were treated with this antibiotic in an open noncomparative study. Clinical responses to therapy were excellent and failures were only encountered with infections caused by Pseudomonas aeruginosa strains that developed resistance during therapy. Superinfection rates were minimal as were toxicities. Imipenem/cilastatin appears to be a relatively safe and highly effective broad spectrum antibiotic.

摘要

亚胺培南/西司他丁是一种新型碳青霉烯类抗生素，具有广谱抗菌活性。在一项开放性非对照研究中，42例患有各种类型感染（包括皮肤和软组织、呼吸道、骨与关节以及泌尿系统感染）的患者接受了这种抗生素治疗。治疗的临床反应良好，仅在治疗期间对亚胺培南产生耐药性的铜绿假单胞菌菌株引起的感染中出现治疗失败情况。二重感染率和毒性均极低。亚胺培南/西司他丁似乎是一种相对安全且高效的广谱抗生素。