Margolis Gilad, Goldhaber Ofir, Kazatsker Mark, Kobo Ofer, Roguin Ariel, Leshem Eran
Division of Cardiovascular Medicine, Hillel Yaffe Medical Center, The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa 38100, Israel.
Cardiac Electrophysiology Unit, Hillel Yaffe Medical Center, Hadera 38100, Israel.
J Clin Med. 2024 Feb 26;13(5):1318. doi: 10.3390/jcm13051318.
Atrial fibrillation (AF) catheter ablation in cancer patients has been evaluated in very few studies. We aimed to investigate utilization trends and in-hospital outcomes of AF catheter ablation among cancer patients in a large US inpatient registry. Utilizing the National Inpatient Sample (NIS) database, patients who underwent AF catheter ablation between 2012 and 2019 were identified. Sociodemographic, clinical data, in-hospital procedures and outcomes were collected. Baseline characteristics and in-hospital outcomes were compared between patients with and without cancer. An estimated total of 67,915 patients underwent AF catheter ablation between 2012 and 2019 in the US. Of them, 950 (1.4%) had a cancer diagnosis. Patients with a cancer diagnosis were older and had higher Charlson Comorbidity Index, CHA2DS2-VASc and ATRIA bleeding indices scores. A higher rate of total complications was observed in cancer patients (10.5% vs. 7.9, < 0.001), driven mainly by more bleeding and infectious complications. However, no significant differences in cardiac or neurological complications as well as in-hospital mortality rates were observed and were relatively low in both groups. AF catheter ablation in cancer patients is associated with higher bleeding and infectious complication rates, but not with increased cardiac complications or in-hospital mortality in a US nationwide, all-comer registry.
关于癌症患者心房颤动（AF）导管消融术的研究非常少。我们旨在调查美国一个大型住院患者登记系统中癌症患者AF导管消融术的使用趋势和住院结局。利用全国住院患者样本（NIS）数据库，确定了2012年至2019年间接受AF导管消融术的患者。收集了社会人口统计学、临床数据、住院期间的手术和结局。比较了有癌症和无癌症患者的基线特征和住院结局。2012年至2019年期间，美国估计共有67915例患者接受了AF导管消融术。其中，950例（1.4%）被诊断患有癌症。患有癌症的患者年龄更大，Charlson合并症指数、CHA2DS2-VASc和ATRIA出血指数得分更高。癌症患者的总并发症发生率更高（10.5%对7.9%，<0.001），主要是由于出血和感染性并发症更多。然而，在心脏或神经并发症以及住院死亡率方面未观察到显著差异，两组的发生率都相对较低。在美国全国范围内的所有患者登记系统中，癌症患者的AF导管消融术与更高的出血和感染性并发症发生率相关，但与心脏并发症增加或住院死亡率无关。
