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两种药物用于拔牙麻醉的效果评估:一项自身对照研究。

Assessment of the Efficiency for Anesthesia of Two Agents in Teeth Removal: A Split-Mouth Research.

作者信息

Khan Pallavi, Gopalakrishnan V, Busani Sasi K, Dash Kailash C, Prabhakar Chinmayi, Purohit Jayendra, Tiwari Rahul

机构信息

Department of Oral Maxillofacial Surgery and Oncosurgery, Annapurna Health Point Hospital, Durgapur, West Bengal, India.

Department of Oral and Maxillofacial Surgery, Army Dental Centre, Research and Referral, Delhi, India.

出版信息

J Pharm Bioallied Sci. 2024 Feb;16(Suppl 1):S149-S151. doi: 10.4103/jpbs.jpbs_431_23. Epub 2024 Feb 29.

Abstract

AIM

This study was intended to assess and relate the clinical anesthetic effectiveness of tramadol hydrochloride and lidocaine.

METHODOLOGY

A clinical randomized split-mouth study was piloted among 40 patients who were otherwise healthy but needed to have their maxillary first premolars extracted bilaterally for orthodontic reasons were considered in the research. In each subject on one side (quadrant) of the arch 1.8 milliliters of lidocaine was given and on other side of the arch 1.8 milliliters of tramadol was given. On the basis of a list that was prepared by a computer, the randomization was done and the sides (quadrant) of the arches were decided for all the subjects, and the injections were given as local infiltration.

RESULTS

Lidocaine was found to be statistically more effective for overall anesthesia duration, despite the fact that there was no significant variance between the two drugs at the time when anesthetic effect began to take effect. Tramadol was found to be statistically more efficient than lidocaine when compared to the anesthetic activity at the 5 minute before extraction. Tramadol was found to be statistically more successful than lidocaine for both the patient's degree of satisfaction and the rate at which wounds healed.

CONCLUSION

Based on the findings of this research, it appears that tramadol and epinephrine could be used as a substitute to conventional local anesthetics during extractions of maxillary first premolar teeth during oral-maxillofacial surgery.

摘要

目的

本研究旨在评估盐酸曲马多和利多卡因的临床麻醉效果并进行相关性分析。

方法

在40名身体健康但因正畸原因需要双侧拔除上颌第一前磨牙的患者中开展了一项临床随机双盲研究。在每位受试者牙弓的一侧(象限)注射1.8毫升利多卡因,另一侧注射1.8毫升曲马多。根据计算机生成的列表进行随机分组,确定所有受试者牙弓的注射侧(象限),并进行局部浸润注射。

结果

尽管在麻醉效果开始起效时两种药物之间无显著差异,但利多卡因在总体麻醉持续时间上在统计学上更有效。与拔牙前5分钟时的麻醉活性相比,曲马多在统计学上比利多卡因更有效。在患者满意度和伤口愈合率方面,曲马多在统计学上比利多卡因更成功。

结论

基于本研究结果,在口腔颌面外科上颌第一前磨牙拔除术中,曲马多和肾上腺素似乎可替代传统局部麻醉剂使用。

相似文献

本文引用的文献

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Four dimensions of fear of dental injections.对牙科注射恐惧的四个维度。
J Am Dent Assoc. 1997 Jun;128(6):756-66. doi: 10.14219/jada.archive.1997.0301.
10
The effect of tramadol on dento-alveolar surgical pain.曲马多对牙槽外科手术疼痛的影响。
Br J Oral Maxillofac Surg. 1997 Feb;35(1):54-8. doi: 10.1016/s0266-4356(97)90012-7.

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