Wang Changsheng, Pan Mengqiu, Lin Qinjian, Mofatteh Mohammad, Chen Yimin, Baizabal-Carvallo José Fidel, Su Fanghua, Wang Zhanhang
Key Specialty of Clinical Pharmacy, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China.
Department of Neurology, GuangDong Sanjiu Brain Hospital, Guangzhou, China.
Heliyon. 2024 Mar 27;10(7):e28630. doi: 10.1016/j.heliyon.2024.e28630. eCollection 2024 Apr 15.
Nontuberculous mycobacteria associated intracranial infection is a rare disease that mainly occurs in HIV-infected patients. The disease has a poor prognosis. The authors report a case of non-tuberculous mycobacterial meningoencephalitis in a non-AIDS patient, but long history of poorly controlled type 2 diabetes mellitus. A 55-year-old, right-handed, male patient presented with an 8-day history of fever, episodes of severe headache with signs of meningeal irritation. MRI showed hyperintensities/contrast enhancement in the visual pathways, basal ganglia sellar region and leptomeninges. No etiological diagnosis was reached until metagenomic next-generation sequencing (mNGS) was used, showing the presence of . The patient was cured with aggressive antimycobacterial therapy. The authors discuss the clinical manifestations and drug therapy of nontuberculous mycobacteria-related intracranial infections by reviewing relevant literature. As meningoencephalitis by has a high mortality an early diagnosis and appropriate therapeutic interventions are warranted. For this reason, the use of mNGS can be helpful to avoid therapeutic delay.
非结核分枝杆菌相关颅内感染是一种罕见疾病，主要发生于HIV感染患者。该疾病预后较差。作者报告了1例非艾滋病患者发生的非结核分枝杆菌性脑膜脑炎病例，但患者有长期控制不佳的2型糖尿病病史。一名55岁、右利手男性患者出现发热8天，伴有严重头痛发作及脑膜刺激征。MRI显示视路、基底节鞍区及软脑膜有高信号/强化。在采用宏基因组下一代测序（mNGS）之前未明确病因诊断，结果显示存在…… 患者经积极抗分枝杆菌治疗后治愈。作者通过回顾相关文献讨论了非结核分枝杆菌相关颅内感染的临床表现及药物治疗。由于……引起的脑膜脑炎死亡率高，因此有必要进行早期诊断和适当的治疗干预。出于这个原因，使用mNGS有助于避免治疗延误。
