肾脏保护策略。
Renoprotective strategies.
作者信息
Raikou Vaia D
机构信息
Department of Nephrology, Doctors'General Clinic, Athens 11257, Greece.
出版信息
World J Nephrol. 2024 Mar 25;13(1):89637. doi: 10.5527/wjn.v13.i1.89637.
Abstract
Kidney disease remains a condition with an increasing incidence, high morbidity and mortality associated with cardiovascular events. The incidence of end-stage renal disease is expected to increase. Despite of the technical improvement, dialysis never achieved a full clearance of the blood dialysis. Therefore, the demand for new renoprotective measures has never been greater. Here, we report new strategies for preventing renal damage.
摘要
肾脏疾病仍然是一种发病率不断上升、发病率高且与心血管事件相关的死亡率高的疾病。终末期肾病的发病率预计会上升。尽管技术有所进步，但透析从未实现血液透析的完全清除。因此，对新的肾脏保护措施的需求从未如此迫切。在此，我们报告预防肾损伤的新策略。
相似文献
1
Renoprotective strategies.肾脏保护策略。
World J Nephrol. 2024 Mar 25;13(1):89637. doi: 10.5527/wjn.v13.i1.89637.
3
Renoprotection with SGLT2 inhibitors in type 2 diabetes over a spectrum of cardiovascular and renal risk.在 2 型糖尿病的一系列心血管和肾脏风险中，SGLT2 抑制剂的肾脏保护作用。
Cardiovasc Diabetol. 2020 Nov 22;19(1):196. doi: 10.1186/s12933-020-01163-9.
4
Renal dysfunction after off-pump coronary artery bypass surgery- risk factors and preventive strategies.非体外循环冠状动脉搭桥术后的肾功能障碍——危险因素及预防策略
Indian J Anaesth. 2009 Aug;53(4):401-7.
5
[REIN Report 2011--summary].[2011年肾脏疾病改善全球结果（KDIGO）报告——摘要]
Nephrol Ther. 2013 Sep;9 Suppl 1:S3-6. doi: 10.1016/S1769-7255(13)70036-1.
6
Renoprotection by blockade of the renin-angiotensin-aldosterone system in diabetic and non-diabetic chronic kidney disease. Specific involvement of intra-renal angiotensin-converting enzyme activity in therapy resistance?糖尿病和非糖尿病慢性肾脏病中通过阻断肾素-血管紧张素-醛固酮系统实现的肾脏保护作用。肾内血管紧张素转换酶活性在治疗抵抗中的具体作用？
Minerva Med. 2004 Oct;95(5):395-409.
7
Prevention of loss of renal function over time in patients with diabetic nephropathy.预防糖尿病肾病患者肾功能随时间的丧失。
Am J Med. 2006 May;119(5 Suppl 1):S40-7. doi: 10.1016/j.amjmed.2006.01.013.
8
Beat it early: putative renoprotective haemodynamic effects of oral hypoglycaemic agents.尽早控制：口服降糖药假定的肾脏保护血流动力学效应
Nephrol Dial Transplant. 2016 Jul;31(7):1036-43. doi: 10.1093/ndt/gfv093. Epub 2015 Apr 8.
9
Early referral strategies for management of people with markers of renal disease: a systematic review of the evidence of clinical effectiveness, cost-effectiveness and economic analysis.早期转介策略在管理有肾脏疾病标志物的人群中的应用：对临床有效性、成本效益和经济分析证据的系统评价。
Health Technol Assess. 2010 Apr;14(21):1-184. doi: 10.3310/hta14210.
10
Integrated therapies including erythropoietin decrease the incidence of dialysis: lessons from mapping the incidence of end-stage renal disease in Japan.包括促红细胞生成素在内的综合治疗可降低透析发生率：来自日本终末期肾病发病率图谱的经验教训。
Nephrol Dial Transplant. 2008 Mar;23(3):984-90. doi: 10.1093/ndt/gfm705. Epub 2007 Oct 23.
引用本文的文献
1
Advancements in the non-invasive diagnosis of renal fibrosis.肾纤维化的非侵入性诊断进展
Front Med (Lausanne). 2025 Jul 30;12:1646412. doi: 10.3389/fmed.2025.1646412. eCollection 2025.
2
Tryptophan metabolism as a target in gut microbiota, ageing and kidney disease.色氨酸代谢作为肠道微生物群、衰老和肾脏疾病的一个靶点。
Int J Biol Sci. 2025 Jun 23;21(10):4374-4387. doi: 10.7150/ijbs.115359. eCollection 2025.
3
Fecal microbiota transplantation is a promising therapy for kidney diseases.粪便微生物群移植是一种很有前景的肾脏疾病治疗方法。
Front Med (Lausanne). 2025 Jul 9;12:1628722. doi: 10.3389/fmed.2025.1628722. eCollection 2025.
4
Yiqi Yangyin Tongluo Recipe Alleviates Diabetic Kidney Disease Through AGE-RAGE Signalling Axis.益气养阴通络方通过AGE-RAGE信号轴减轻糖尿病肾病
Diabetes Metab Syndr Obes. 2025 Jun 28;18:2041-2055. doi: 10.2147/DMSO.S523784. eCollection 2025.
5
Critical Review of the Benefit from Early Pharmacological and Dietary Support for Patients with Moderate-to-Severe (Non-Terminal) Chronic Kidney Disease.对中重度（非终末期）慢性肾病患者早期药物和饮食支持益处的批判性综述
Biomedicines. 2025 Apr 19;13(4):994. doi: 10.3390/biomedicines13040994.
6
Unleashing the pathological role of epithelial-to-mesenchymal transition in diabetic nephropathy: The intricate connection with multifaceted mechanism.揭示上皮-间质转化在糖尿病肾病中的病理作用：与多方面机制的复杂联系。
World J Nephrol. 2024 Jun 25;13(2):95410. doi: 10.5527/wjn.v13.i2.95410.
本文引用的文献
1
Pemafibrate inhibited renal dysfunction and fibrosis in a mouse model of adenine-induced chronic kidney disease.佩马贝特在腺嘌呤诱导的慢性肾病小鼠模型中抑制肾功能障碍和纤维化。
Life Sci. 2023 May 15;321:121590. doi: 10.1016/j.lfs.2023.121590. Epub 2023 Mar 20.
2
Empagliflozin in Patients with Chronic Kidney Disease.恩格列净在慢性肾脏病患者中的应用。
N Engl J Med. 2023 Jan 12;388(2):117-127. doi: 10.1056/NEJMoa2204233. Epub 2022 Nov 4.
3
In advanced CKD with poorly controlled hypertension, chlorthalidone reduced BP at 12 wk.在高血压控制不佳的晚期慢性肾脏病患者中，氯噻酮在12周时降低了血压。
Ann Intern Med. 2022 Mar;175(3):JC29. doi: 10.7326/J22-0007. Epub 2022 Mar 1.
4
Cardiovascular and kidney outcomes with finerenone in patients with type 2 diabetes and chronic kidney disease: the FIDELITY pooled analysis.在 2 型糖尿病合并慢性肾脏病患者中，用非奈利酮治疗的心血管和肾脏结局：FIDELITY 汇总分析。
Eur Heart J. 2022 Feb 10;43(6):474-484. doi: 10.1093/eurheartj/ehab777.
5
Exosomes isolated from melatonin-stimulated mesenchymal stem cells improve kidney function by regulating inflammation and fibrosis in a chronic kidney disease mouse model.从褪黑素刺激的间充质干细胞中分离出的外泌体，通过调节慢性肾病小鼠模型中的炎症和纤维化来改善肾功能。
J Tissue Eng. 2021 Nov 29;12:20417314211059624. doi: 10.1177/20417314211059624. eCollection 2021 Jan-Dec.
6
Chlorthalidone for Hypertension in Advanced Chronic Kidney Disease.氯沙坦治疗晚期慢性肾脏病的高血压。
N Engl J Med. 2021 Dec 30;385(27):2507-2519. doi: 10.1056/NEJMoa2110730. Epub 2021 Nov 5.
7
Dyslipidemia in Patients with Kidney Disease.肾病患者的血脂异常。
Cardiol Clin. 2021 Aug;39(3):353-363. doi: 10.1016/j.ccl.2021.04.008.
8
KDIGO 2021 Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease.KDIGO 2021慢性肾脏病血压管理临床实践指南
Kidney Int. 2021 Mar;99(3S):S1-S87. doi: 10.1016/j.kint.2020.11.003.
9
Metabolic and Anti-inflammatory Response to Melatonin Administration in Patients with Diabetic Nephropathy.褪黑素对糖尿病肾病患者的代谢及抗炎反应
Iran J Kidney Dis. 2021 Jan;1(1):22-30.
10
Disorders in bone-mineral parameters and the risk of death in persons with chronic kidney disease stages 4 and 5: the PECERA study.慢性肾脏病 4 期和 5 期患者的骨矿物质参数紊乱与死亡风险：PECERA 研究。
J Nephrol. 2021 Aug;34(4):1189-1199. doi: 10.1007/s40620-020-00916-9. Epub 2021 Jan 4.
Zotero 插件