Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico.
Clínica de Especialidades Gastrointestinales y Hepáticas, Hospital Star Medica, Merida 97133, Yucatan, Mexico.
World J Gastroenterol. 2024 Mar 14;30(10):1313-1328. doi: 10.3748/wjg.v30.i10.1313.
Cirrhosis is considered a growing cause of morbidity and mortality, which represents a significant public health problem. Currently, there is no effective treatment to reverse cirrhosis. Treatment primarily centers on addressing the underlying liver condition, monitoring, and managing portal hypertension-related complications, and evaluating the potential for liver transplantation in cases of decompensated cirrhosis, marked by rapid progression and the emergence of complications like variceal bleeding, hepatic encephalopathy, ascites, malnutrition, and more. Malnutrition, a prevalent complication across all disease stages, is often underdiagnosed in cirrhosis due to the complexities of nutritional assessment in patients with fluid retention and/or obesity, despite its crucial impact on prognosis. Increasing emphasis has been placed on the collaboration of nutritionists within hepatology and Liver transplant teams to deliver comprehensive care, a practice that has shown to improve outcomes. This review covers appropriate screening and assessment methods for evaluating the nutritional status of this population, diagnostic approaches for malnutrition, and context-specific nutrition treatments. It also discusses evidence-based recommendations for supplementation and physical exercise, both essential elements of the standard care provided to cirrhotic patients.
肝硬化是发病率和死亡率不断上升的原因,是一个重大的公共卫生问题。目前,尚无有效的治疗方法可以逆转肝硬化。治疗主要集中在治疗潜在的肝脏疾病、监测和管理与门脉高压相关的并发症,并评估在失代偿性肝硬化(以快速进展和出现静脉曲张出血、肝性脑病、腹水、营养不良等并发症为特征)情况下进行肝移植的可能性。营养不良是所有疾病阶段的常见并发症,但由于液体潴留和/或肥胖患者的营养评估复杂,肝硬化患者的营养不良常常被漏诊,尽管其对预后有重要影响。营养学家在肝病学和肝移植团队中的协作以提供全面的护理越来越受到重视,这种做法已被证明可以改善预后。本综述涵盖了评估该人群营养状况的适当筛查和评估方法、营养不良的诊断方法以及特定于具体情况的营养治疗方法。它还讨论了补充剂和体育锻炼的循证建议,这是为肝硬化患者提供标准护理的两个重要组成部分。