Dahl A R, Coslett D S, Bond J A, Hesseltine G R
J Natl Cancer Inst. 1985 Jul;75(1):135-9.
The formation of metabolites of nasally instilled benzo[a]pyrene [(BP) CAS: 50-32-8] was determined. The study was prompted by a report that a high incidence of tumors occurred in tissues of the upper respiratory and alimentary tracts of Syrian hamsters exposed to BP aerosols. The esophagi of anesthetized hamsters were surgically catheterized so that radiolabeled material instilled as BP in the nose could be collected and analyzed for metabolites. About 50% of the instilled BP was metabolized in the nose and, potentially, would have been swallowed in an awake animal. In auxiliary experiments, homogenates of respiratory and alimentary tissues were tested for metabolic activity for BP. The nose, trachea, and lungs had about equally high activities on a per organ basis (5-7 nmol/hr), whereas all other tissues had considerably less activity. The results of the study indicate that nasal metabolism may be important in causing tumors in alimentary as well as upper respiratory tissues.
对经鼻腔滴注苯并[a]芘[（BP），化学物质登记号：50-32-8]后代谢物的形成情况进行了测定。有报告称，暴露于BP气雾剂的叙利亚仓鼠的上呼吸道和消化道组织中肿瘤发生率很高，由此引发了本研究。对麻醉后的仓鼠进行手术，将导管插入其食管，以便收集经鼻腔滴注的作为BP的放射性标记物质，并分析其代谢物。约50%滴注的BP在鼻腔中被代谢，在清醒动物中这些代谢物可能会被吞咽下去。在辅助实验中，对呼吸和消化组织的匀浆进行了BP代谢活性测试。以每个器官计算，鼻腔、气管和肺的活性大致相同（5 - 7纳摩尔/小时），而所有其他组织的活性则低得多。研究结果表明，鼻腔代谢在引发消化道以及上呼吸道组织的肿瘤方面可能具有重要作用。
