Universidad Peruana de Ciencias Aplicadas, Lima, Perú.
Universidad Privada Norbert Wiener, Lima, Perú.
Rev Peru Med Exp Salud Publica. 2023 Out-Dec;40(4):432-440. doi: 10.17843/rpmesp.2023.404.12957.
OBJECTIVES.: To determine the association between the degree of severity of COVID-19 infection during pregnancy and preterm premature rupture of membranes (PPROM) in a level III hospital in Peru.
MATERIALS AND METHODS.: Cross-sectional, analytical and observational study in women older than 18 years diagnosed with COVID-19 infection during pregnancy, between the years 2020 and 2022. Clinical and obstetric variables were collected. The chi-square and Fisher's exact tests were used for the descriptive analysis. For the multivariate analysis, we calculated the prevalence ratio by using Poisson regression in crude and adjusted models. All statistical tests were performed considering a value of p<0.05 as significant and with a confidence level of 95%.
RESULTS.: We analyzed data from 163 pregnant women with COVID-19, of which 9.2% had PPROM; all were symptomatic cases. Mild COVID-19 cases were 1.10 times more likely to have PPROM (RPa=1.10; 95%CI: 1.02-1.18) and moderate/severe cases were 1.64 times more likely (RPa=1.64; 95%CI: 1.43-1.87), compared to asymptomatic cases.
CONCLUSIONS.: We identified that a higher degree of severity of COVID-19 infection during pregnancy was associated with a higher probability of having PPROM.
在秘鲁的一家三级医院确定 COVID-19 感染孕妇的严重程度与胎膜早破（PPROM）之间的关联。
这是一项在 2020 年至 2022 年间诊断为 COVID-19 感染的 18 岁以上孕妇中进行的横断面、分析性和观察性研究。收集了临床和产科变量。采用卡方检验和 Fisher 精确检验进行描述性分析。对于多变量分析，我们使用泊松回归在粗模型和调整模型中计算患病率比。所有统计检验均采用 p<0.05 作为显著性水平，置信水平为 95%。
我们分析了 163 名患有 COVID-19 的孕妇的数据，其中 9.2%患有 PPROM；所有病例均为有症状病例。轻度 COVID-19 病例发生 PPROM 的可能性高 1.10 倍（RPa=1.10；95%CI：1.02-1.18），中度/重度病例发生 PPROM 的可能性高 1.64 倍（RPa=1.64；95%CI：1.43-1.87），与无症状病例相比。
我们发现，COVID-19 感染孕妇的严重程度越高，发生胎膜早破的可能性越大。
