Universidad Peruana de Ciencias Aplicadas, Lima, Perú.
Centro de Excelencia en Investigaciones Económicas y Sociales en Salud, Facultad de Ciencias Empresariales, Universidad San Ignacio de Loyola, Lima, Perú.
Rev Peru Med Exp Salud Publica. 2023 Jan-Mar;40(1):34-41. doi: 10.17843/rpmesp.2023.401.11205. Epub 2023 Jun 23.
OBJECTIVES.: To determine the association between symptoms of COVID-19 infection and adverse maternal-perinatal outcomes in pregnant women from a referral hospital.
MATERIALS AND METHODS.: Analytical cross-sectional study of women in the third trimester of pregnancy hospitalized due to COVID-19 in the gynecology and obstetrics area of a general hospital in Lima during 2020. Clinical and obstetric variables were collected. Fisher's exact test and Chi-square test were used during the descriptive analysis. Poisson regression was used to find the association between the variables of interest, with a 95% confidence interval (95%CI).
RESULTS.: A total of 272 pregnant women were included, 50.3% of whom had symptoms of infection. Of these, 35.7% of the pregnant women and 16.5% of the newborns had an adverse outcome. Having symptoms of COVID-19 infection increased the risk of maternal complications as a whole (PR= 2.32 95%CI: 1.61-3.34), premature rupture of membranes (PR= 2.73 95%CI: 1.51-4.94) and preeclampsia (PR= 2.73 95%CI: 1.51-4.94). Similarly, symptoms of COVID-19 infection increased the risk of perinatal complications as a whole (PR= 2.51 95%CI: 1.34-4.68) and acute fetal distress (PR= 2.99 95%CI: 1.07-8.38).
CONCLUSIONS.: The presence of symptoms of COVID-19 infection increase the risk of adverse maternal-perinatal outcomes.
确定在利马一家综合医院妇产科因 COVID-19 住院的孕妇中，COVID-19 感染症状与不良母婴围产结局之间的关联。
这是一项 2020 年针对利马一家综合医院妇产科因 COVID-19 住院的孕妇的回顾性病例对照研究。收集了临床和产科变量。描述性分析中使用 Fisher 确切检验和卡方检验。使用泊松回归来发现感兴趣变量之间的关联，置信区间为 95%（95%CI）。
共纳入 272 名孕妇，其中 50.3%有感染症状。其中，35.7%的孕妇和 16.5%的新生儿出现不良结局。有 COVID-19 感染症状会增加母体并发症的整体风险（PR=2.32 95%CI：1.61-3.34）、胎膜早破（PR=2.73 95%CI：1.51-4.94）和子痫前期（PR=2.73 95%CI：1.51-4.94）。同样，COVID-19 感染症状也会增加围产儿并发症的整体风险（PR=2.51 95%CI：1.34-4.68）和急性胎儿窘迫（PR=2.99 95%CI：1.07-8.38）。
COVID-19 感染症状的存在会增加不良母婴围产结局的风险。
