Pérez-Prieto Inmaculada, Rodríguez-Santisteban Aida, Altmäe Signe
Department of Biochemistry and Molecular Biology, Faculty of Sciences, University of Granada.
Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain.
Curr Opin Obstet Gynecol. 2024 Apr 17. doi: 10.1097/GCO.0000000000000952.
The analysis of microbiome in association with female health is today a "hot topic" with the main focus on microbes in the female reproductive tract. Nevertheless, recent studies are providing novel information of the possible influence of the gut microbiome on gynecological health outcomes, especially as we start to understand that the gut microbiome is an extended endocrine organ influencing female hormonal levels. This review summarizes the current knowledge of the gut microbes in association with gynecological health.
The gut microbiome has been associated with endometriosis, polycystic ovary syndrome, gynecological cancers, and infertility, although there is a lack of consistency and consensus among studies due to different study designs and protocols used, and the studies in general are underpowered.
The interconnection between the gut microbiome and reproductive health is complex and further research is warranted. The current knowledge in the field emphasizes the link between the microbiome and gynecological health outcomes, with high potential for novel diagnostic and treatment tools via modulation of the microenvironment.
如今，分析微生物群与女性健康的关系是一个“热门话题”，主要聚焦于女性生殖道中的微生物。然而，最近的研究正在提供有关肠道微生物群对妇科健康结果可能产生影响的新信息，尤其是当我们开始认识到肠道微生物群是一个影响女性激素水平的扩展内分泌器官时。本综述总结了目前关于肠道微生物与妇科健康相关的知识。
肠道微生物群与子宫内膜异位症、多囊卵巢综合征、妇科癌症和不孕症有关，尽管由于使用的研究设计和方案不同，研究之间缺乏一致性和共识，而且总体而言这些研究的样本量不足。
肠道微生物群与生殖健康之间的联系很复杂，有必要进行进一步研究。该领域目前的知识强调了微生物群与妇科健康结果之间的联系，通过调节微环境开发新型诊断和治疗工具的潜力很大。
