Department of Biochemistry and Molecular Biology, Faculty of Sciences, University of Granada.
Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain.
Curr Opin Clin Nutr Metab Care. 2024 Jun 1;36(3):134-147. doi: 10.1097/01.gco.0001016536.06312.72. Epub 2024 Apr 8.
The analysis of microbiome in association with female health is today a "hot topic" with the main focus on microbes in the female reproductive tract. Nevertheless, recent studies are providing novel information of the possible influence of the gut microbiome on gynecological health outcomes, especially as we start to understand that the gut microbiome is an extended endocrine organ influencing female hormonal levels. This review summarizes the current knowledge of the gut microbes in association with gynecological health.
The gut microbiome has been associated with endometriosis, polycystic ovary syndrome, gynecological cancers, and infertility, although there is a lack of consistency and consensus among studies due to different study designs and protocols used, and the studies in general are underpowered.
The interconnection between the gut microbiome and reproductive health is complex and further research is warranted. The current knowledge in the field emphasizes the link between the microbiome and gynecological health outcomes, with high potential for novel diagnostic and treatment tools via modulation of the microenvironment.
目前，微生物组与女性健康的分析是一个“热门话题”，主要关注女性生殖道中的微生物。然而，最近的研究提供了肠道微生物组可能对妇科健康结果产生影响的新信息，特别是因为我们开始理解肠道微生物组是一个影响女性激素水平的扩展内分泌器官。本文综述了肠道微生物组与妇科健康相关的最新知识。
肠道微生物组与子宫内膜异位症、多囊卵巢综合征、妇科癌症和不孕有关，尽管由于使用的研究设计和方案不同，研究之间缺乏一致性和共识，而且总体而言研究力度不足。
肠道微生物组与生殖健康之间的相互关系很复杂，需要进一步研究。该领域的现有知识强调了微生物组与妇科健康结果之间的联系，通过调节微环境，为新型诊断和治疗工具提供了很高的潜力。
