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工程菌用于癌症免疫治疗。

Engineering Microorganisms for Cancer Immunotherapy.

机构信息

Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, No. 639 Longmian Avenue, Nanjing, 211198, China.

Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & Nanjing Medical University Affiliated Cancer Hospital, Nanjing, 210009, China.

出版信息

Adv Healthc Mater. 2024 Jul;13(18):e2304649. doi: 10.1002/adhm.202304649. Epub 2024 Apr 21.

Abstract

Cancer immunotherapy presents a promising approach to fight against cancer by utilizing the immune system. Recently, engineered microorganisms have emerged as a potential strategy in cancer immunotherapy. These microorganisms, including bacteria and viruses, can be designed and modified using synthetic biology and genetic engineering techniques to target cancer cells and modulate the immune system. This review delves into various microorganism-based therapies for cancer immunotherapy, encompassing strategies for enhancing efficacy while ensuring safety and ethical considerations. The development of these therapies holds immense potential in offering innovative personalized treatments for cancer.

摘要

癌症免疫疗法是一种利用免疫系统对抗癌症的有前途的方法。最近,工程微生物已成为癌症免疫疗法中的一种潜在策略。这些微生物包括细菌和病毒,可以使用合成生物学和基因工程技术进行设计和修饰,以靶向癌细胞并调节免疫系统。本综述深入探讨了各种基于微生物的癌症免疫疗法,包括增强疗效的策略,同时确保安全性和伦理考虑。这些疗法的发展为癌症提供了创新的个性化治疗方法,具有巨大的潜力。

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