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贪食症饥饿状态下的代谢和内分泌指标:与神经性厌食症的比较。

Metabolic and endocrine indices of starvation in bulimia: a comparison with anorexia nervosa.

作者信息

Pirke K M, Pahl J, Schweiger U, Warnhoff M

出版信息

Psychiatry Res. 1985 May;15(1):33-9. doi: 10.1016/0165-1781(85)90037-x.

DOI:10.1016/0165-1781(85)90037-x
PMID:3859882
Abstract

Fifteen patients with bulimia (DSM-III) and 22 patients with anorexia nervosa (10 "restricters" and 12 "vomiters") were compared with 24 age- and sex-matched healthy controls. Serial blood samples were collected between 8:30 and 9:30 a.m. with patients in supine and standing positions. Elevated blood values of beta-hydroxybutyric acid and free fatty acids were observed in the majority of patients with bulimia and anorexia nervosa. These data indicate that many patients with bulimia showed the metabolic signs of starvation at the time of the study, a finding supported by the symptoms of endocrine adaptation to starvation, namely low triiodothyronine and a decreased noradrenaline response to an orthostatic test in many of these patients.

摘要

将15名神经性贪食症患者(依据《精神疾病诊断与统计手册》第三版)和22名神经性厌食症患者(10名“限制型”和12名“呕吐型”)与24名年龄和性别匹配的健康对照者进行了比较。上午8:30至9:30之间采集系列血样,患者分别处于仰卧位和站立位。在大多数神经性贪食症和神经性厌食症患者中观察到β-羟基丁酸和游离脂肪酸的血液值升高。这些数据表明,许多神经性贪食症患者在研究时呈现出饥饿的代谢体征,这一发现得到了内分泌适应饥饿症状的支持,即在许多此类患者中三碘甲状腺原氨酸水平较低,且对直立试验的去甲肾上腺素反应降低。

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Metabolic and endocrine indices of starvation in bulimia: a comparison with anorexia nervosa.贪食症饥饿状态下的代谢和内分泌指标:与神经性厌食症的比较。
Psychiatry Res. 1985 May;15(1):33-9. doi: 10.1016/0165-1781(85)90037-x.
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Serum levels of S100B are decreased in chronic starvation and normalize with weight gain.
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The effect of neuroendocrine secretion on brain morphology and EEG sleep in patients with eating disorders.
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