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抑郁症:关注单核细胞。

Depression: Monocytes on my mind.

机构信息

Center for Social and Affective Neuroscience, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

Center for Social and Affective Neuroscience, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

出版信息

Immunity. 2024 Apr 9;57(4):837-839. doi: 10.1016/j.immuni.2024.03.011.

DOI:10.1016/j.immuni.2024.03.011
PMID:38599175
Abstract

Activation of the peripheral immune system contributes to stress-related neuropsychiatric symptoms. Recently in Nature, Cathomas et al. demonstrate that stress-induced social avoidance is mediated by monocyte-derived MMP8 that remodels the extracellular space of the nucleus accumbens.

摘要

外周免疫系统的激活有助于与压力相关的神经精神症状。最近在《自然》杂志上,Cathomas 等人表明,应激诱导的社会回避是由单核细胞衍生的 MMP8 介导的,MMP8 重塑了伏隔核的细胞外空间。

相似文献

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Depression: Monocytes on my mind.抑郁症:关注单核细胞。
Immunity. 2024 Apr 9;57(4):837-839. doi: 10.1016/j.immuni.2024.03.011.
2
Circulating myeloid-derived MMP8 in stress susceptibility and depression.应激易感性和抑郁症中的循环髓系衍生 MMP8。
Nature. 2024 Feb;626(8001):1108-1115. doi: 10.1038/s41586-023-07015-2. Epub 2024 Feb 7.
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Peripheral immune-derived matrix metalloproteinase promotes stress susceptibility.外周免疫源性基质金属蛋白酶促进应激易感性。
Res Sq. 2023 Jan 30:rs.3.rs-1647827. doi: 10.21203/rs.3.rs-1647827/v1.
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Neuronal Nitric Oxide Synthase in Nucleus Accumbens Specifically Mediates Susceptibility to Social Defeat Stress through Cyclin-Dependent Kinase 5.伏隔核神经元型一氧化氮合酶通过细胞周期蛋白依赖性激酶 5 特异性介导对社会挫败应激的易感性。
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Mefloquine in the nucleus accumbens promotes social avoidance and anxiety-like behavior in mice.伏隔核中的甲氟喹促进小鼠的社交回避和焦虑样行为。
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Psychological stress induces depressive-like behavior associated with bone marrow-derived monocyte infiltration into the hippocampus independent of blood-brain barrier disruption.心理应激诱导与血脑屏障破坏无关的骨髓源性单核细胞浸润海马的抑郁样行为。
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引用本文的文献

1
Peripheral Blood Mononuclear Cell Biomarkers for Major Depressive Disorder: A Transcriptomic Approach.用于重度抑郁症的外周血单核细胞生物标志物:一种转录组学方法。
Depress Anxiety. 2024 Oct 3;2024:1089236. doi: 10.1155/2024/1089236. eCollection 2024.