膀胱尿路上皮癌中的骨基质骨化生：一种不常见且具有挑战性的特征。病例报告。

Stromal osseous metaplasia in urothelial carcinoma of the bladder: An unusual and challenging feature. A case report.

机构信息

Department of Pathology, University Hospital A Coruña, A Coruña, Galicia, Spain.

出版信息

Rev Esp Patol. 2024 Apr-Jun;57(2):116-119. doi: 10.1016/j.patol.2023.09.002. Epub 2023 Nov 20.

DOI:10.1016/j.patol.2023.09.002

Abstract

A 62-year-old male presented with pain and haematuria starting 3 months before. The computed tomography showed focal and mural bladder thickening with ureteropelvic dilatation. The following transurethral bladder resection revealed a high-grade muscle-invasive urothelial carcinoma. In the subsequent cystoprostatectomy we found the same tumour, but adding focal tumour-associated stromal osseous metaplasia. Ossifying metaplasia is an extremely rare feature in urothelial carcinoma, with a few reported cases and represents a diagnostic challenge, mimicking radiotherapy-induced sarcoma or sarcomatoid carcinoma.

摘要

一位 62 岁男性，3 个月前出现疼痛和血尿。计算机断层扫描显示膀胱局灶性和壁性增厚伴肾盂输尿管扩张。随后的经尿道膀胱切除术显示高级别肌层浸润性尿路上皮癌。在随后的膀胱前列腺切除术时，我们发现了同样的肿瘤，但伴有局灶性肿瘤相关的间质骨化生。骨化性化生是尿路上皮癌的一种极为罕见的特征，仅有少数报道病例，具有诊断挑战性，类似于放射治疗引起的肉瘤或肉瘤样癌。