基于 CaCO 基磁性微马达与石墨烯场效应晶体管集成的传染病现场检测。
On-site detection of infectious disease based on CaCO-based magnetic micromotor integrated with graphene field effect transistor.
机构信息
Inner Mongolia Key Laboratory of Carbon Nanomaterials, Nano Innovation Institute (NII), College of Chemistry and Materials Science, Inner Mongolia Minzu University, Tongliao, 028000, People's Republic of China.
Key Laboratory of Mongolian Medicine Research and Development Engineering, Ministry of Education, Inner Mongolia Minzu University, Tongliao, 028000, People's Republic of China.
出版信息
Mikrochim Acta. 2024 Apr 11;191(5):257. doi: 10.1007/s00604-024-06345-w.
A new detection platform based on CaCO-based magnetic micromotor (CaCO@FeO) integrated with graphene field effect transistor (GFET) was construct and used for on-site SARS-CoV-2 coronavirus pathogen detection. The CaCO@FeO micromotor, which was modified with anti-SARS-CoV-2 (labelled antibody, AntiE1), can self-moved in the solution containing hydrochloric acid (HCl) and effective to capture the SARS-CoV-2 coronavirus pathogens. After magnetic field separation, the capture micromotor was detected by GFET, exhibiting a good linear relationship within the range of 1 ag/mL to 100 ng/mL and low detection limit (0.39 ag/mL). Furthermore, the detection platform was also successfully applied to detection of SARS-CoV-2 coronavirus pathogens in soil solution, indicating the potential use in on-site application.
构建了一种基于 CaCO 基磁性微马达（CaCO@FeO）与石墨烯场效应晶体管（GFET）集成的新型检测平台，用于现场 SARS-CoV-2 冠状病毒病原体检测。经过抗 SARS-CoV-2（标记抗体，AntiE1）修饰的 CaCO@FeO 微马达可以在含有盐酸（HCl）的溶液中自行移动，有效地捕获 SARS-CoV-2 冠状病毒病原体。经过磁场分离后，用 GFET 检测捕获的微马达，在 1 ag/mL 至 100 ng/mL 的范围内呈现出良好的线性关系，检测限低（0.39 ag/mL）。此外，该检测平台还成功应用于土壤溶液中 SARS-CoV-2 冠状病毒病原体的检测，表明其在现场应用中的潜力。
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