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胃食管反流病与肠易激综合征的因果关联：一项两样本孟德尔随机化研究。

Causal association of gastroesophageal reflux disease on irritable bowel syndrome: a two-sample Mendelian randomization study.

作者信息

Wu Huihuan, Li Jingwei, Li FeiFei, Lun Weijian

机构信息

Department of Gastroenterology, The Sixth Affiliated Hospital, School of Medicine, South China University of Technology, Foshan, Guangdong, China.

Department of Gastroenterology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.

出版信息

Front Genet. 2024 Mar 27;15:1328327. doi: 10.3389/fgene.2024.1328327. eCollection 2024.

DOI:10.3389/fgene.2024.1328327

PMID:38601073

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11004226/

Abstract

BACKGROUND

Recently, observational studies have reported that gastroesophageal reflux disease (GERD) is commonly associated with irritable bowel syndrome (IBS), but the causal relationship is unclear.

METHODS

We conducted a two-sample Mendelian randomization study using summary data from genome-wide association studies (GWASs) to explore a causal relationship between GERD (N cases = 129,080) and IBS (N cases = 4,605) of European ancestry. Furthermore, the inverse-variance weighted (IVW) method and a series of sensitivity analyses were used to assess the accuracy and confidence of our results.

RESULTS

We found a significant association of GERD with IBS (NSNP = 74; OR: 1.375; 95% CI: 1.164-1.624; < 0.001). Reverse MR analysis showed no evidence of a causal association for IBS with GERD (NSNP = 6; OR: 0.996; 95% CI: 0.960-1.034; = 0.845).

CONCLUSION

This study provides evidence that the presence of GERD increases the risk of developing IBS, and it is observed from the reverse MR results that IBS did not increase the risk of GERD.

摘要

背景

最近，观察性研究报告称胃食管反流病（GERD）通常与肠易激综合征（IBS）相关，但因果关系尚不清楚。

方法

我们使用全基因组关联研究（GWAS）的汇总数据进行了一项两样本孟德尔随机化研究，以探讨欧洲血统的GERD（病例数N = 129,080）和IBS（病例数N = 4,605）之间的因果关系。此外，采用逆方差加权（IVW）方法和一系列敏感性分析来评估我们结果的准确性和可信度。

结果

我们发现GERD与IBS之间存在显著关联（单核苷酸多态性数量NSNP = 74；比值比OR：1.375；95%置信区间CI：1.164 - 1.624；P < 0.001）。反向孟德尔随机化分析未显示IBS与GERD存在因果关联的证据（NSNP = 6；OR：0.996；95% CI：0.960 - 1.034；P = 0.845）。