Ke Hong Hong, Li Jinyi, Liang Guicheng, Li Shuhu, Wang Shirong, Zhong Guoqiang
Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Department of Cardiology, The Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, China.
SAGE Open Med. 2024 Apr 8;12:20503121241243247. doi: 10.1177/20503121241243247. eCollection 2024.
To evaluate the correlation of oxidative stress and vascular endothelial dysfunction with hippocampal perfusion in patients with atrial fibrillation and cognitive impairment.
In total, 41 atrial fibrillation patients with cognitive impairment were compared to 45 atrial fibrillation patients without cognitive impairment. Oxidative stress, vascular endothelial dysfunction, hippocampal perfusion, and cognitive function were measured.
Serum level of oxidized low-density lipoprotein was significantly higher in the atrial fibrillation + cognitive impairment group than in the atrial fibrillation group. Serum levels of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 were significantly higher, and nitric oxide was lower, in the atrial fibrillation + cognitive impairment group than in the atrial fibrillation group. The regional cerebral blood volume, mean transit time, and time to peak were significantly higher in the atrial fibrillation + cognitive impairment group than in the atrial fibrillation group. Moreover, regional cerebral blood flow was significantly lower in the atrial fibrillation + cognitive impairment group than in the atrial fibrillation group. Age, left atrial diameter, and regional cerebral blood volume were negatively correlated with the cognitive function score in the atrial fibrillation + cognitive impairment group. Serum levels of oxidized low-density lipoprotein, regional cerebral blood volume, regional cerebral blood flow, mean transit time, and time to peak were significantly correlated with cognitive impairment in atrial fibrillation patients after multivariate logistic regression analysis.
Hippocampal perfusion and oxidative stress were significantly correlated with cognitive impairment in atrial fibrillation patients.
评估房颤合并认知障碍患者氧化应激和血管内皮功能障碍与海马灌注之间的相关性。
共纳入41例房颤合并认知障碍患者，并与45例无认知障碍的房颤患者进行比较。检测氧化应激、血管内皮功能障碍、海马灌注及认知功能。
房颤合并认知障碍组氧化型低密度脂蛋白血清水平显著高于房颤组。房颤合并认知障碍组细胞间黏附分子-1和血管细胞黏附分子-1血清水平显著升高，一氧化氮水平降低。房颤合并认知障碍组局部脑血容量、平均通过时间和达峰时间显著高于房颤组。此外，房颤合并认知障碍组局部脑血流显著低于房颤组。在房颤合并认知障碍组中，年龄、左心房直径和局部脑血容量与认知功能评分呈负相关。多因素逻辑回归分析后，氧化型低密度脂蛋白血清水平、局部脑血容量、局部脑血流、平均通过时间和达峰时间与房颤患者认知障碍显著相关。
房颤患者海马灌注和氧化应激与认知障碍显著相关。
