Potturi Abhinand, Reddy N Viveka Vardhan, Rajan Ritesh, Kumar Jhawar Dinesh, Bharath Y W
SVS Institute of Dental Sciences, Hyderabad, Telangana India.
J Maxillofac Oral Surg. 2024 Apr;23(2):356-362. doi: 10.1007/s12663-023-02108-x. Epub 2024 Feb 8.
Open reduction and internal fixation (ORIF) of the anterior mandibular fractures are commonly associated with mental nerve paraesthesia. This study evaluates the efficacy of melatonin on postoperative sensory functional recovery and pain following surgical treatment of anterior mandibular fractures.
Forty patients were randomly allocated to two groups: Group I-melatonin, and Group II-control group. Postoperative neurosensory recovery was evaluated both subjectively and objectively at 1-week, 1-month, and 3-month intervals. The pain was assessed during the immediate postoperative period, postoperative days 1, 2, 3, and 7 using a visual analog scale. Statistical significance was set at value < 0.05.
The statistically significant difference was noticed in both subjective and objective recovery of sensory nerve function at 1-month follow-up. All patients in the melatonin group showed complete recovery of nerve function as compared to the control group where 10% of patients showed limited recovery.
Neurosensory recovery following ORIF of mandibular fractures was better in the melatonin group as compared to the control group and therefore the perioperative administration of 10 mg. Melatonin can be recommended for quicker and better nerve recovery in the anterior mandibular fractures requiring close manipulation of the mental nerve during treatment.
下颌前部骨折的切开复位内固定术（ORIF）常伴有颏神经感觉异常。本研究评估褪黑素对下颌前部骨折手术治疗后感觉功能恢复及疼痛的疗效。
40例患者随机分为两组：I组为褪黑素组，II组为对照组。术后分别在1周、1个月和3个月时对神经感觉恢复情况进行主观和客观评估。术后即刻、术后第1、2、3和7天使用视觉模拟量表评估疼痛程度。设定统计学显著性水平为P值<0.05。
在1个月的随访中，感觉神经功能的主观和客观恢复均存在统计学显著差异。与对照组相比，褪黑素组所有患者的神经功能均完全恢复，而对照组有10%的患者恢复有限。
与对照组相比，褪黑素组在下颌骨折切开复位内固定术后的神经感觉恢复情况更好，因此对于治疗期间需要对颏神经进行精细操作的下颌前部骨折，建议围手术期给予10mg褪黑素，以实现更快、更好的神经恢复。
